EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

RANKL in the osteolysis of AES total ankle replacement implants



RANKL in the osteolysis of AES total ankle replacement implants



Bone 51(3): 546-552



Peri-implant tissue reactions in failed total ankle replacement (TAR) are characterized by early developing peri-implant osteolysis. The hypothesis of the study was that this reaction is mediated by receptor activator of nuclear factor kappa B ligand (RANKL). Samples of peri-prosthetic tissues from failed TAR implants were stained for macrophages, RANKL, its receptor RANK and osteoprotegerin (OPG), and compared to control samples. The failed TAR implants were surrounded by implant capsule, synovial lining-like interface membrane or necrotic tissues. Infiltrating scavenger receptor I positive CD163(+) macrophages were frequent, in particular around necrotic soft tissues or bone sequestrate, and possibly in part formed due to ischemia and mechanical factors. In contrast, implant-derived wear debris was scanty. Still many RANK(+) macrophages were often seen in close contact with RANKL(+) mesenchymal cells, whereas OPG was mostly located at a distance in vascular endothelial cells. Foreign body giant cells were frequent. RANKL seems to stimulate locally accumulated CD163(+) RANK-expressing cells to fusion, which leads to the local formation of multinuclear foreign body giant cells (and probably of osteoclasts). Therefore, peri-implant osteolysis in early TAR implant failure seems to be caused by the RANKL-driven chronic foreign body inflammation directed against, not implant-derived particles, but against necrotic autologous tissues.

(PDF emailed within 0-6 h: $19.90)

Accession: 055333166

Download citation: RISBibTeXText

PMID: 22627031

DOI: 10.1016/j.bone.2012.05.007



Related references

Periprosthetic aseptic osteolysis in total ankle replacement: cause and management. Clinics in Podiatric Medicine and Surgery 30(2): 145-155, 2013

Periprosthetic osteolysis after AES total ankle replacement: Conventional radiography versus CT-scan. Foot and Ankle Surgery 21(3): 164-170, 2016

Management of Massive Hindfoot Osteolysis Secondary to Failed INBONE I Total Ankle Replacement. Clinics in Podiatric Medicine and Surgery 32(4): 595-607, 2016

Autoinflammation Around AES Total Ankle Replacement Implants. Foot & Ankle International 36(12): 1455-1462, 2016

Increased expression and processing of ADAM 12 (meltrin-alpha) in osteolysis associated with aseptic loosening of total hip replacement implants. Journal of Rheumatology 32(10): 1943-1950, 2005

Management of Extensive Talar Osteolysis with Agilitya Total Ankle Replacement Systems Using Geometric Metal-Reinforced Polymethylmethacrylate Cement Augmentation. 2013

Management of extensive talar osteolysis with Agility™ total ankle replacement systems using geometric metal-reinforced polymethylmethacrylate cement augmentation. Journal of Foot and Ankle Surgery 53(1): 108-113, 2014

Management of Extensive Talar Osteolysis with Agilitya Total Ankle Replacement Systems Using Geometric Metal-Reinforced Polymethylmethacrylate Cement Augmentation. 2013

Management of extensive tibial osteolysis with the Agility™ total ankle replacement systems using geometric metal-reinforced polymethylmethacrylate cement augmentation. Journal of Foot and Ankle Surgery 53(1): 101-107, 2014

The Efficacy of Platelet-Rich Plasma for Incision Healing After Total Ankle Replacement Using the Agility Total Ankle Replacement System. Foot & Ankle International 37(4): 373-377, 2015

Intermediate to Long-Term Outcomes of Total Ankle Replacement with the Scandinavian Total Ankle Replacement (STAR). Journal of Bone and Joint Surgery. American Volume 97(11): 895-903, 2015

Initial hospital-related cost comparison of total ankle replacement and ankle fusion with hip and knee joint replacement. Foot & Ankle International 36(3): 253-257, 2015

Total ankle replacement and contralateral ankle arthrodesis in 16 patients from the Swedish Ankle Registry: Self-reported function and satisfaction. Foot and Ankle Surgery 22(1): 32-34, 2016

Total ankle replacement or ankle fusion in painful advanced hemophilic arthropathy of the ankle. Expert Review of Hematology 8(6): 727-731, 2016

Trends in treatment of advanced ankle arthropathy by total ankle replacement or ankle fusion. Foot & Ankle International 35(3): 216-224, 2014