+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

RAP1: protector of telomeres, defender against obesity

RAP1: protector of telomeres, defender against obesity

Cell Reports 3(6): 1757-1758

Telomere dysfunction has previously been linked to metabolic disorders. In this issue of Cell Reports, Martínez et al. (2013) and Yeung et al. (2013) now extend this link, demonstrating that deletion of the telomere binding protein RAP1 leads to obesity and insulin resistance.

(PDF emailed within 0-6 h: $19.90)

Accession: 055333259

Download citation: RISBibTeXText

PMID: 23809762

DOI: 10.1016/j.celrep.2013.06.011

Related references

Telomeres and inflammation: Rap1 joins the ends?. Cell Cycle 9(19): 3834-3835, 2011

Rap1 affects the length and heterogeneity of human telomeres. Molecular Biology of the Cell 14(12): 5060-5068, 2003

The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms. Embo Journal 22(7): 1697-1706, 2003

Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast. Genes & Development 9(3): 370-384, 1995

The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. Journal of Cell Biology 134(6): 1349-1363, 1996

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation. Journal of Biological Chemistry 276(30): 28478-28483, 2001

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 63(4): 739-750, 1990

Identification of new yeast genes important for the localization of telomeres and Rap1 protein in yeast nuclei. Journal of Cellular Biochemistry Supplement 0(18C): 106, 1994

Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity. Cell Reports 3(6): 1847-1856, 2014

RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Reports 3(6): 2059-2074, 2014

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance. Aging Cell (): -, 2016

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Developmental Cell 7(4): 585-595, 2004

SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1. Journal of Cell Science 128(23): 4341-4352, 2016

The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes. Journal of Biological Chemistry 290(18): 11455-11466, 2015