+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects

RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects

Current Hypertension Reviews 9(2): 93-98

Recent studies have suggested that blood-brain barrier (BBB) abnormalities are present from an early stage in patients exhibiting mild symptoms of cognitive impairment during the development of hypertension. There is also growing body of evidence suggesting the potential role of the renin-angiotensin system (RAS) in the pathogenesis of small-vessel disease and cognitive impairment. However, the specific contribution of the RAS to BBB disruption and cognitive impairment remains unclear. We found a significant leakage from brain microvessels in the hippocampus and impaired cognitive functions in angiotensin II (AngII)-infused hypertensive mice, which were associated with increased brain AngII levels. These changes were not observed in AngII-infused AT1a receptor (-/-) mice. We also observed that Dahl salt-sensitive hypertensive rats exhibited hypertension, leakage from brain microvessels in the hippocampus, and impaired cognitive function. In these animals, treatment with an AngII receptor blocker, olmesartan, did not alter blood pressure, but markedly ameliorated leakage from brain microvessels and restored the cognitive decline. These data support the hypothesis that RAS inhibition attenuates cognitive impairment by reducing BBB injury, which is independent of blood pressure changes.

(PDF emailed within 1 workday: $29.90)

Accession: 055333381

Download citation: RISBibTeXText

PMID: 23971690

Related references

RAS Inhibition Attenuates Cognitive Impairment by Reducing Blood- Brain Barrier Permeability in Hypertensive Subjects. 2013

Blood-brain barrier permeability abnormalities in vascular cognitive impairment. Stroke 42(8): 2158-2163, 2012

Granulocyte Colony-Stimulating Factor Attenuates Blood-Brain Barrier Damage and Improves Cognitive Function in Spontaneously Hypertensive Rats. Cns & Neurological Disorders Drug Targets 16(7): 781-788, 2017

Inhibition of T-cell activation attenuates hypertension, TNFα, IL-17, and blood-brain barrier permeability in pregnant rats with angiogenic imbalance. American Journal of Reproductive Immunology 76(4): 272-279, 2016

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. American Journal of Physiology. Heart and Circulatory Physiology, 2018

Changes in blood-brain barrier permeability, choroid plexus blood flow and brain extracellular fluid volume in hypertensive rats. Society for Neuroscience Abstracts 27(1): 1481, 2001

Intracerebral administration of neuronal nitric oxide synthase antiserum attenuates traumatic brain injury-induced blood-brain barrier permeability, brain edema formation, and sensory motor disturbances in the rat. Acta Neurochirurgica. Supplement 96: 288-294, 2006

Carbonic anhydrase inhibition and changes in the permeability of the blood--brain--cerebrospinal fluid--aqueous barrier. Studies on the haematoencephalic barrier. VII. Acta Physiologica Academiae Scientiarum Hungaricae 20: 81-88, 1961

TIMP-1 attenuates blood–brain barrier permeability in mice with acute liver failure. Journal of Cerebral Blood Flow & Metabolism 33(7): 1041-1049, 2013

Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model. Journal of Inflammation 15: 4-4, 2018

Dissociation of changes in the permeability of the blood-brain barrier from catecholamine-induced changes in blood pressure of normotensive and spontaneously hypertensive rats. Research Communications in Chemical Pathology and Pharmacology 37(3): 343-354, 1982

Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. Brain Research 1051(1-2): 72-80, 2005

20-HETE Inhibition by HET0016 Decreases the Blood-Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury. Frontiers in Aging Neuroscience 10: 207-207, 2018

Role of AT1 receptors in permeability of the blood-brain barrier in diabetic hypertensive rats. Vascular Pharmacology 45(3): 141-147, 2006

Effect of losartan on the blood-brain barrier permeability in diabetic hypertensive rats. Life Sciences 73(25): 3235-3244, November 7, 2003