EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression



RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression



Molecular Biology International 2012: 154283-154283



The RASSF proteins are a family of polypeptides, each containing a conserved Ras association domain, suggesting that these scaffold proteins may be effectors of activated Ras or Ras-related small GTPases. RASSF proteins are characterized by their ability to inhibit cell growth and proliferation while promoting cell death. RASSF1 isoform A is an established tumor suppressor and is frequently silenced in a variety of tumors and human cancer cell lines. However, our understanding of its function in terminally differentiated cell types, such as cardiac myocytes, is relatively nascent. Herein, we review the role of RASSF1A in cardiac physiology and disease and highlight signaling pathways that mediate its function.

(PDF emailed within 0-6 h: $19.90)

Accession: 055333472

Download citation: RISBibTeXText

PMID: 22577551

DOI: 10.1155/2012/154283



Related references

When RASSF1A RAN into tumor suppression: Ran GTPase is a RASSF1A effector involved in controlling microtubule organization. Cell Cycle 8(23): 3796-3797, 2010

Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation. Cellular Physiology and Biochemistry 48(3): 1259-1273, 2018

The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway. Tumour Biology 37(7): 8869-8877, 2016

Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression. Journal of Biological Chemistry 289(45): 31287-31295, 2015

Relationship between the expression of RASSF1A protein and promoter hypermethylation of RASSF1A gene in bladder tumor. Journal of Huazhong University of Science and Technology. Medical Sciences 28(2): 182-184, 2008

Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions. Journal of Biological Chemistry 286(21): 18483-18491, 2011

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. Journal of Biological Chemistry 279(28): 29247-29254, 2004

The tumor suppressor RAS-association domain family protein 1A (RASSF1A) regulates TNF-alpha signaling in cardiomyocytes. European Heart Journal 34(Suppl 1): 36-36, 2013

The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Molecular Cell 18(6): 637-650, 2005

NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression. Oncotarget 7(17): 23395-23415, 2016

Matching of chemotherapy to mouse strain and lymphoid tumor type to prevent tumor-induced suppression of specific T- and B-cell functions. Cancer Research 39(11): 4564-4574, 1979

Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. Journal of Mammary Gland Biology and Neoplasia 16(3): 205-219, 2012

MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression. Plos One 9(1): E86839-E86839, 2014

Longitudinal analysis of various heart and blood circulation functions in children during and after an acute infectious disease. 3. Volume elasticity coefficient, total peripheral resistance, suppression factor, heart work, heart output, pulse duration-primary vibration period and Hegglin's syndrome. Zeitschrift für Arztliche Fortbildung 62(23): 1279-1287, 1968

Conserved RB functions in development and tumor suppression. Protein & Cell 2(11): 864-878, 2012