EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

RB regulation of developmental transcriptional programs



RB regulation of developmental transcriptional programs



Fly 5(2): 115-118



Inactivation of the retinoblastoma protein (pRB) is a hallmark of human cancer. Accordingly the RB pathway has been extensively studied in mammals, flies and worms, but mostly in the context of cell cycle entry. The means by which RB proteins regulate differentiation and the transcription of genes involved in differentiation and development is less well understood. We have examined how Drosophila RB proteins regulate differentiation-specific genes in proliferating cells. We found that the mechanism of repression differs from what has been observed at cell cycle regulated genes (Figure 1). Two different chromatin modifications present at different locations contribute to the repression of such genes. We argue that this represents a novel mechanism of repression and that this type of regulation by RB proteins warrants further attention.

(PDF emailed within 0-6 h: $19.90)

Accession: 055333547

Download citation: RISBibTeXText

PMID: 21150287

DOI: 10.4161/fly.5.2.14187



Related references

Developmental changes in mouse gonadotropin-releasing hormone gene expression Transcriptional and post-transcriptional regulation. Society for Neuroscience Abstracts 21(1-3): 264, 1995

Expression of the onco developmental gene alpha feto protein evidence for transcriptional and post transcriptional regulation. Clinical Research 31(2): 412A, 1983

Developmental regulation of Fc epsilon RII/CD23 expression in B-lineage cells: evidence for transcriptional and post-transcriptional levels of control. Immunology Letters 44(2-3): 157-162, 1995

Controlling transcriptional programs for cellular adaptation by chromatin regulation. Molecular Biosystems 7(5): 1713-1719, 2011

Regulation of global transcriptional programs by the MEK1,2/ERK1,2 MAPK pathway. Proceedings of the American Association for Cancer Research Annual Meeting 44: 252-253, July, 2003

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. Cell Reports 12(2): 229-243, 2016

Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice. Sleep 33(11): 1439-1446, 2011

Developmental transcriptional regulation by SUMOylation, an evolving field. Genesis (): -, 2016

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes & Development 22(10): 1397-1409, 2008

Transcriptional regulation of developmental gene expression in Myxococcus xanthus. Dworkin, M, Kaiser, D Myxobacteria, II: 183-199, 1993

Physiological function as regulation of large transcriptional programs: The cellular response to genotoxic stress. Comparative Biochemistry & Physiology Part B Biochemistry & Molecular Biology 129B(4): 703-710, July, 2001

Cyclic dimeric GMP signaling and regulation of surface-associated developmental programs. Journal of Bacteriology 190(3): 781-783, 2007

Regulation of functionally related enzymes during alternative developmental programs. Biochimica et Biophysica Acta 244(2): 388-395, 1971

HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity. Clinical & Developmental Immunology 2012: 678705-678705, 2012