+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis

RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis

Developmental Biology 332(2): 339-350

Neurogenesis persists in restricted regions of the adult vertebrate brain. However, the molecular mechanisms supporting adult neurogenesis are not fully understood. Here we demonstrated that C cell-specific deletion of RBP-J in the adult subventricular zones (SVZs) caused reduction in numbers of mature granule cells in the olfactory bulbs (OBs) with concomitant increase in Olig2(+) oligodendroglial progenitors, although generation of immature neurons was enhanced in the SVZs. Adenovirus-mediated Cre introduction to the SVZs of RBP-J-floxed mice indicated that Olig2(+) cells in the OBs can be generated from RBP-J-deficient SVZs, although no oligodendroglial cells in the OBs are derived from the normal SVZs. This preferential differentiation to oligodendroglial progenitor cells and reduction in differentiation of mature neurons were also confirmed by in vitro culture of RBP-J-deficient SVZ-derived neural progenitor cells, in addition to defects in the maintenance of adult neural stem cell population. The defects in maturation of RBP-J-deficient neurons could be partly rescued by knockdown of Olig2 in vivo. Our findings suggest that RBP-J might regulate neuronal maturation at least in part through transcriptional repression of Olig2.

(PDF emailed within 0-6 h: $19.90)

Accession: 055333671

Download citation: RISBibTeXText

PMID: 19501584

DOI: 10.1016/j.ydbio.2009.06.001

Related references

ASK1 inhibits astroglial development via p38 mitogen-activated protein kinase and promotes neuronal differentiation in adult hippocampus-derived progenitor cells. Molecular and Cellular Biology 24(1): 280-293, 2003

Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation. Bmc Neuroscience 11(): 48-48, 2010

Hes6 inhibits astrocyte differentiation and promotes neurogenesis through different mechanisms. Journal of Neuroscience 26(43): 11061-11071, 2006

Sonic hedgehog enhances both neuronal and oligodendroglial differentiation and inhibits the actions of BMP2 on cultured progenitor cells. Society for Neuroscience Abstracts 24(1-2): 1527, 1998

Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104(3): 5-76, 2001

Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro. Neuroscience 250: 614-621, 2014

Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323(5917): 1074-1077, 2009

Hippocalcin Promotes Neuronal Differentiation and Inhibits Astrocytic Differentiation in Neural Stem Cells. Stem Cell Reports 8(1): 95-111, 2016

Collagen type IV promotes the differentiation of neuronal progenitors and inhibits astroglial differentiation in cortical cell cultures. Developmental Brain Research. 110(1): 31-38,. 10, 1998

Lineage-specific regulation of neurogenesis PACAP inhibits proliferation and promotes differentiation of cerebral cortical precursors. Society for Neuroscience Abstracts 20(1-2): 1487, 1994

Hypoxic ischaemic hypothermia promotes neuronal differentiation and inhibits glial differentiation from newly generated cells in the SGZ of the neonatal rat brain. Neuroscience Letters 523(1): 87-92, 2012

Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate. Journal of Neuroscience 29(6): 1826-1833, 2009

SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. Journal of Neuroscience 32(9): 3067-3080, 2012

Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells. Biochemical and Biophysical Research Communications 293(1): 167-173, 2002

Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis. Pharmacology, Biochemistry, and Behavior 116: 55-63, 2014