+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis



RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis



Plos One 6(8): E22889



The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis. The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice. Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challenged with Mycobacterium tuberculosis infection. The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protection against M. tuberculosis infection.

(PDF emailed within 0-6 h: $19.90)

Accession: 055333956

Download citation: RISBibTeXText

PMID: 21853054

DOI: 10.1371/journal.pone.0022889


Related references

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. Plos One 9(7): E101764, 2015

A multistage mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis. Human Vaccines and Immunotherapeutics 12(7): 1670-1677, 2017

Latency antigen α-crystallin based vaccination imparts a robust protection against TB by modulating the dynamics of pulmonary cytokines. Plos One 6(4): E18773, 2011

A subunit vaccine based on rH-NS induces protection against Mycobacterium tuberculosis infection by inducing the Th1 immune response and activating macrophages. Acta Biochimica et Biophysica Sinica 48(10): 909-922, 2016

Long term local b cell memory in murine lymph nodes draining a primary antigen injection. Federation Proceedings 40(3 PART 2): 1133, 1981

Polyadp - ribosylation is a correlate of long - term memory after training inducing long - term sensitization of withdrawal reflexes in Aplysia. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 92 9, 2003

The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine. International Immunology 10(1): 17-25, 1998

Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer. Plos One 5(5): E10471, 2010

Intranasal immunization with protective antigen of Bacillus anthracis induces a long-term immunological memory response. Molecular Immunology 67(2 Pt B): 492-500, 2015

Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia. Clinical and Vaccine Immunology 23(10): 813-824, 2016

Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations. Tuberculosis 101: 174-190, 2017

Impairment of long-term memory and sparing of short-term memory in monkeys with medial temporal lobe lesions: a response to Ringo. Behavioural Brain Research 52(1): 1-5, 1992

Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after nonsterile protection by a cytotoxic T-lymphocyte-based vaccine. Journal of Virology 81(10): 5202-5211, 2007

Long-term, two-stage chemotherapy of advanced experimental murine tuberculosis with intermittent regimes during the second stage. Tubercle 44: 236-240, 1963