+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

RNA polymerase III transcription - regulated by chromatin structure and regulator of nuclear chromatin organization



RNA polymerase III transcription - regulated by chromatin structure and regulator of nuclear chromatin organization



Sub-Cellular Biochemistry 61: 261-287



RNA polymerase III (Pol III) transcription is regulated by modifications of the chromatin. DNA methylation and post-translational modifications of histones, such as acetylation, phosphorylation and methylation have been linked to Pol III transcriptional activity. In addition to being regulated by modifications of DNA and histones, Pol III genes and its transcription factors have been implicated in the organization of nuclear chromatin in several organisms. In yeast, the ability of the Pol III transcription system to contribute to nuclear organization seems to be dependent on direct interactions of Pol III genes and/or its transcription factors TFIIIC and TFIIIB with the structural maintenance of chromatin (SMC) protein-containing complexes cohesin and condensin. In human cells, Pol III genes and transcription factors have also been shown to colocalize with cohesin and the transcription regulator and genome organizer CCCTC-binding factor (CTCF). Furthermore, chromosomal sites have been identified in yeast and humans that are bound by partial Pol III machineries (extra TFIIIC sites - ETC; chromosome organizing clamps - COC). These ETCs/COC as well as Pol III genes possess the ability to act as boundary elements that restrict spreading of heterochromatin.

(PDF emailed within 0-6 h: $19.90)

Accession: 055336735

Download citation: RISBibTeXText

PMID: 23150255

DOI: 10.1007/978-94-007-4525-4_12


Related references

Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-ribose) polymerase-1: possible targets for drug-based therapies. Sub-Cellular Biochemistry 41: 45-69, 2007

The Fun30 chromatin remodeler Fft3 controls nuclear organization and chromatin structure of insulators and subtelomeres in fission yeast. Plos Genetics 11(3): E1005101, 2015

Structure of interphase macro nuclear chromatin of a ciliate bursaria truncatella 2. loop organization of inactive chromatin clumps/. Molekulyarnaya Biologiya 18(1): 272-276, 1984

Regulated processive transcription of chromatin by T7 RNA polymerase in Trypanosoma brucei. Nucleic Acids Research 26(20): 4626-4634, 1998

Cell-free transcription of mammalian chromatin: transcription of globin messenger RNA sequences from bone-marrow chromatin with mammalian RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America 71(4): 1219-1223, 1974

Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Nucleus 2(5): 358-369, 2012

Biochemical analysis of basal and regulated transcription by rna polymerase ii with reconstituted chromatin templates. Journal of Biomolecular Structure & Dynamics 8(6): A116, 1991

Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function. Cellular and Molecular Life Sciences 71(21): 4089-4113, 2014

The study of chromatin and chromosome structure on preparations of interphase nucleus derivatives resulting from nuclear wall removal.III Structural heterogeneity of chromatin and argyrophilic zone of the nucleolus in stretched membrane-free nuclei and chromatin bodies from human peripheral lymphocytes. Tsitologiia 42(5): 473-485, 2000

Structure of eukaryotic chromosomes and chromatin part 1 conformational flexibility in dna structure and its implications in understanding the organization of dna in chromatin/. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 295-298, 1978

Chromatin insulators and boundaries: effects on transcription and nuclear organization. Annual Review of Genetics 35: 193-208, 2001

Structure of Eukaryotic Chromosomes and Chromatin || Conformational Flexibility in DNA Structure and Its Implications in Understanding the Organization of DNA in Chromatin. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 283(997): 295-298, 1978

Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation. Bmc Biology 13: 35, 2016

Structure of eukaryotic chromosomes and chromatin part 3 chromatin transcription with mercurated nucleotides. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 379-380, 1978

Structure of Eukaryotic Chromosomes and Chromatin || Chromatin Transcription with Mercurated Nucleotides. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 283(997): 379-380, 1978