EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Behçet's disease



RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Behçet's disease



Journal of Neuroimmunology 233(1-2): 249-253



Neurological manifestations are present in 5% to 30% of patients with Behçet's disease (BD). Neuro-Behçet's Disease (NBD) is hypothetically caused by T helper (Th) cells, which development is dependent on the expression of lineage-specific transcription factors. Cerebrospinal fluid (CSF) mRNA expression of TBX21, GATA3, RORC, FOXP3 and EBI3 were assessed in 18 NBD patients and 26 controls disease [16 noninflammatory neurological disease (NIND) and 10 headache attributed to Behçet's disease (HaBD)]. Expression of TBX21 (Th1), RORC (Th17) and Foxp3 (Treg) were increased in NBD patients compared to HaBD and NIND patients. EBI3 and Th2-associated GATA3 expressions were found to be decreased (P<0.0001 and P<0.0001) in NBD patients. Analysis of transcription factor ratios, revealed an increase in the RORC/FOXP3 and TBX21/GATA3 ratios in NBD patients (P<0.0001; P<0.0003). Our findings indicate that both Th1 and Th17 mRNA expressions involving a possible impairment of Treg cells. This might play a role in CSF-NBD inflammation, permitting activation of harmful T cell subpopulations. The TBX21/GATA3 and RORC/FOXP3 ratios dysregulations in NBD are consistent with those reported in other inflammatory diseases and indicating the plasticity existing between Th1, Th17 and Treg cells during inflammation.

(PDF emailed within 0-6 h: $19.90)

Accession: 055338250

Download citation: RISBibTeXText

PMID: 21367463

DOI: 10.1016/j.jneuroim.2011.01.012



Related references

Cytological examination of cerebrospinal fluid in eight patients with neuro-Behçet's disease. Tohoku Journal of Experimental Medicine 132(4): 421-430, 1980

Macrophage migration inhibitory factor in the cerebrospinal fluid of patients with conventional and optic-spinal forms of multiple sclerosis and neuro-Behcet's disease. Journal of the Neurological Sciences 179(1-2): 127-131, October 1, 2000

Elevated levels of MMP-9 and TIMP-1 in the cerebrospinal fluid of neuro-Behçet's disease. Clinical and Experimental Rheumatology 27(2 Suppl 53): S52-S57, 2010

Soluble Fas ligand levels in cerebrospinal fluid in neuro-Behçet's disease. Advances in Experimental Medicine and Biology 528: 389-391, 2003

Elevated BAFF Levels in the Cerebrospinal Fluid of Patients with Neuro-Behcet’s Disease BAFF is Correlated with Progressive Dementia and Psychosis. 2012

Anticardiolipin antibodies and interleukin-6 in cerebrospinal fluid and blood of Chinese patients with neuro-Behçet's syndrome. Clinical and Experimental Rheumatology 10(6): 599-602, 1992

Humoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behçet patients. Clinical and Experimental Immunology 113(1): 100-104, 1998

Humoral immune response to mycobacterial heat shock protein 65 in the cerebrospinal fluid of neuro-Behcet patients. Journal of the Neurological Sciences 150(SUPPL ): S311, 1997

Transcriptional characteristics of CD4 T cells in young asthmatic children: RORC and FOXP3 axis. Journal of Inflammation Research 4(): 139-146, 2012

Disc electrophoretic analysis of cerebrospinal fluid proteins in the disturbances of optic nerve. I. Comparison of cerebrospinal fluid at various sites in the cerebrospinal axis. With special reference to the cerebrospinal fluid in the chiasmatic cistern. Nippon Ganka Gakkai Zasshi 74(9): 1129-1135, 1970

Cerebrospinal fluid interleukin-6 in progressive neuro-Behcet's syndrome. Clinical Immunology & Immunopathology 82(1): 12-17, 1997