+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Radiation-induced melanoma-associated leucoderma, systemic antimelanoma immunity and disease-free survival in a patient with advanced-stage melanoma: a case report and immunological analysis



Radiation-induced melanoma-associated leucoderma, systemic antimelanoma immunity and disease-free survival in a patient with advanced-stage melanoma: a case report and immunological analysis



British Journal of Dermatology 168(4): 733-738



Melanoma is an immunogenic tumour. The development of skin depigmentation or melanoma-associated leucoderma (MAL) has been associated with favourable clinical outcome in patients with metastatic melanoma, especially after immunotherapy. Evidence for clinically meaningful enhancement of melanoma-directed autoimmunity, as indicated by MAL, after radiotherapy without immunotherapy has not yet been published. We investigated whether a patient with stage IV melanoma, who developed leucoderma in the irradiated skin areas following radiotherapy and experienced exceptional disease-free survival of 3 years despite brain metastasis, possessed antimelanoma immunity that could be linked to the favourable disease course. A detailed immunological analysis was performed consisting of immunohistochemistry of several melanoma tissues, and analyses of T cells isolated from the blood and MAL skin tissue for melanocyte/melanoma specificity and functionality, as well as the presence of a melanoma-specific antibody response. Immunological analyses showed the presence of CD8+ T cells and antibody responses directed against melanocyte differentiation antigens expressed in the primary tumour, lymph node and brain metastasis, indicating adequate tumour recognition by activated T cells. The immune responses found in this patient, probably enhanced by radiotherapy, are thought to have contributed to his favourable clinical course. Radiotherapy may act as local immunotherapy in patients with melanoma by destroying melanocytes, leading to the induction, or enhancement, of already existent antimelanoma immunity. As in patients treated with immunotherapy, this may lead to MAL, also at distant sites from the treated area. This patient is a clear example of the positive prognostic value of MAL, which is possibly induced by radiotherapy, for patients with melanoma.

(PDF emailed within 0-6 h: $19.90)

Accession: 055345254

Download citation: RISBibTeXText

PMID: 23421690

DOI: 10.1111/bjd.12136


Related references

Radiation induced melanoma-associated-leukoderma, systemic anti-melanoma immunity and disease-free survival in an advanced-stage melanoma patient A case report and immunological analysis. 2013

Humoral antimelanoma immunity: induction by mouse antiidiotypic mAb, MK2-23 and association with survival of patients with advanced melanoma. Mount Sinai Journal of Medicine, New York 59(3): 234-237, 1992

On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients. Clinical Cancer Research 10(14): 4754-4760, 2004

Nivolumab-induced colitis in a patient with malignant melanoma: A case report and immunological analysis. Journal of Dermatology 2019, 2019

Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients. Cancer Immunology, ImmunoTherapy 55(4): 451-458, 2005

Humoral immune response in disease-free advanced melanoma patients after vaccination with melanoma-associated gangliosides. EORTC Cooperative Melanoma Group. International Journal of Cancer 49(6): 893-899, 1991

Persistency of tumor specific T cells in peripheral blood lymphocytes during eight years of disease-free survival of a stage III malignant melanoma patient. Tumori 86(4 Suppl 1): 6, July-August, 2000

Low prognostic importance of non-radical melanoma excision and the presence of melanoma cells in the re-excision specimen to overall and disease-free survival of melanoma patients. Nederlands Tijdschrift Voor Geneeskunde 152(42): 2288-2293, 2008

Melanoma-specific CD8+ T lymphocytes correlate with progressive disease in advanced-stage melanoma patients. Immunobiology 203(1-2): 562, 2000

Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study). European Journal of Cancer 45(18): 3189-3197, 2010

Nivolumab-induced new-onset seronegative rheumatoid arthritis in a patient with advanced metastatic melanoma: A case report and literature review. Avicenna Journal of Medicine 8(1): 34-36, 2018

Immunological responses to vaccinia melanoma oncolysate associated with improved disease free survival. Proceedings of the American Association for Cancer Research Annual Meeting 28: 375, 1987

Pilot study of immunotherapy with melanoma associated gangliosides in disease free advanced melanoma patients. Anticancer Research 10(5 PART B): 1474, 1990

Long-term disease-free survival following dendritic cell therapy and resection of small bowel melanoma metastases - a case report. Anticancer Research 31(10): 3579-3583, 2011

Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma. Human Pathology 44(10): 2071-2074, 2013