+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Randomized comparison of Mohs micrographic surgery and surgical excision for small nodular basal cell carcinoma: tissue-sparing outcome



Randomized comparison of Mohs micrographic surgery and surgical excision for small nodular basal cell carcinoma: tissue-sparing outcome



Dermatologic Surgery 35(9): 1349-1354



Mohs micrographic surgery (MMS) is recognized globally as the criterion standard for high-risk basal cell carcinoma (BCC). The main advantage of MMS over conventional surgery is the chance of complete tumor removal, but it is also thought, based on experience, to be tissue sparing. To determine whether MMS leaves smaller surgical defects than standard surgery. This was a randomized trial involving 30 patients with a clinical diagnosis of BCC. Patients were randomly assigned to MMS or standard surgery. In the standard surgery group the BCCs were excised with 4-mm margins. In the MMS group, tumors were excised with 2-mm margins and subsequent stages of MMS until the tumor was completely removed. An observer unaware of the treatment allocation calculated the defect size. The main outcome measure was defect size in mm(2). The median area of the surgical defects in the MMS group was 116.6 mm(2), versus 187.7 mm(2) in the standard surgery group (95% confidence interval for difference=61-126, p<.001). This is the first randomized trial demonstrating that MMS is a tissue-sparing treatment. http://www.clinicaltrials.gov Identifier: NCT00571363. The authors have indicated no significant interest with commercial supporters.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055357418

Download citation: RISBibTeXText

PMID: 19500127

DOI: 10.1111/j.1524-4725.2009.01240.x


Related references

Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma. Journal of the American Academy of Dermatology 80(6): 1700-1703, 2019

Mohs micrographic surgery versus surgical excision for periocular basal cell carcinoma. Cochrane Database of Systematic Reviews 2012(2): Cd007041, 2012

Mohs micrographic surgery versus surgical excision for periocular basal cell carcinoma. Cochrane Database of Systematic Reviews 2014(12): Cd007041, 2014

Mohs micrographic surgery versus surgical excision for periocular basal cell carcinoma. Cochrane Database of Systematic Reviews 2009(2): Cd007041, 2009

Cost-effectiveness of Mohs Micrographic Surgery vs Surgical Excision for Basal Cell Carcinoma of the Face. Yearbook of Dermatology and Dermatologic Surgery 2007: 321-322, 2007

Cost-effectiveness of Mohs micrographic surgery vs surgical excision for basal cell carcinoma of the face. Archives of Dermatology 142(9): 1235; Author Reply 1235-6, 2006

The Cost-Effectiveness of MOHS Micrographic Surgery Versus Surgical Excision in Basal Cell Carcinoma. Plastic & Reconstructive Surgery 126: 82-83, 2010

Surgical excision vs Mohs' micrographic surgery for basal-cell carcinoma of the face: randomised controlled trial. Lancet 364(9447): 1766-1772, 2004

Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study. British Journal of Dermatology 167(1): 110-115, 2012

Standard surgical excision and reconstruction of giant basal cell carcinoma of the face: may be an alternative to the Mohs micrographic surgery. Journal of the European Academy of Dermatology and Venereology 28(11): 1572-1573, 2014

Imiquimod 5% Cream as Pre-Treatment of Mohs Micrographic Surgery for Nodular Basal Cell Carcinoma in the Face, A Prospective Randomized Controlled Study Imiquimod As Pre-Treatment of Mohs. 2012

Surgical excision versus Mohs' micrographic surgery for basal cell carcinoma of the face: A randomised clinical trial with 10 year follow-up. European Journal of Cancer 50(17): 3011-3020, 2014

Randomized, controlled surgical trial of preoperative tumor curettage of basal cell carcinoma in Mohs micrographic surgery. Journal of the American Academy of Dermatology 51(4): 585-591, 2004

Surgical excision versus Mohs' micrographic surgery for primary and recurrent basal-cell carcinoma of the face: a prospective randomised controlled trial with 5-years' follow-up. Lancet. Oncology 9(12): 1149-1156, 2008

Excision of a Peristomal Basal Cell Carcinoma Using Mohs Micrographic Surgery. Dermatologic Surgery 34(7): 971-973, 2008