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Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: case report and literature review



Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: case report and literature review



Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 108(3): E80-E85



Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumour regarded as the malignant counterpart of ameloblastic fibroma. It is characterized by a benign epithelial component within a malignant fibrous stroma. AFS is a locally aggressive neoplasm with extremely low potential for metastasis. We report an extremely rare, rapidly progressive, and fatal case originating in the posterior mandible of a 20-year old female patient. Initially histopathologically diagnosed as a benign lesion, it rapidly recurred with apparent transformation into a high-grade sarcoma over a period of 6 months. Subsequent intracranial and pulmonary metastases were noted, and the patient died within 15 months of initial consultation. This case emphasizes the need for a high element of suspicion about clinically ambiguous lesions. We recommend more extensive or radical, primary excisions in lesions that have a known potential for recurrence or malignancy.

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Accession: 055367259

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PMID: 19716496

DOI: 10.1016/j.tripleo.2008.07.031


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