+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Rapid urinary trypsinogen-2 test strip in the diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography



Rapid urinary trypsinogen-2 test strip in the diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography



Pancreas 40(8): 1211-1214



The aim of this prospective study was to evaluate the diagnostic value of the rapid urinary trypsinogen-2 test strip in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. A total of 150 patients were tested with the urinary trypsinogen-2 test strip and serum levels of amylase and lipase before ERCP and 3 hours after ERCP. The diagnostic value of urinary trypsinogen-2 strip test compared with that of serum amylase and lipase was analyzed. Post-ERCP pancreatitis was diagnosed in 13 (8.7%) of 150 patients. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of urinary trypsinogen-2 dipstick test at 3 hours after ERCP are 84.6%, 97.1%, 73.3%, 98.5%, and 96%, respectively. At the cutoff level of 3 times the upper reference limit, the negative predictive values of amylase and lipase were comparable to that urinary trypsinogen-2 strip test; however, their positive predictive values (42.9% and 36.4%, respectively) were markedly lower than that of urinary trypsinogen-2 test (73.3%). The urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-ERCP pancreatitis. A negative urinary dipstick test at 3 hours after the procedure rules out post-ERCP pancreatitis with a high probability and allows of early discharge plan.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055368085

Download citation: RISBibTeXText

PMID: 21946810

DOI: 10.1097/mpa.0b013e31821fcdcf


Related references

Use of the urinary trypsinogen-2 dip stick test in early diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography. Surgical Endoscopy 21(8): 1312-1315, 2007

Rapid urinary trypsinogen-2 test strip in the diagnosis of acute pancreatitis. Pancreas 30(3): 243-247, 2005

Urinary trypsinogen-2 test strip, a new rapid test for the early diagnosis of acute pancreatitis. Gastroenterology 110(4 Suppl. ): A397, 1996

Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis. World Journal of Gastroenterology 11(46): 7261-7265, 2005

Assessment of trypsinogen-2 levels as an early diagnostic for post-endoscopic retrograde cholangiopancreatography pancreatitis. Pancreas 40(8): 1206-1210, 2011

Pancreolauryl test, glucose tolerance test and endoscopic retrograde cholangiopancreatography in the diagnosis and monitoring of chronic pancreatitis. Polski Tygodnik Lekarski 50(1-35): 791-793, 1995

Enzyme leakage, trypsinogen activation, and inflammatory response in endoscopic retrograde cholangiopancreatography-induced pancreatitis. Pancreas 24(4): 321-328, 2002

Serum and urine trypsinogen activation peptide in assessing post-endoscopic retrograde cholangiopancreatography pancreatitis. Pancreas 39(1): 108-110, 2010

Mo1237 - Rapid Urinary Trypsinogen Test in Early Point-of-Care Diagnosis of Acute Pancreatitis and Post-Ercp Pancreatitis: A Systematic Review. Gastroenterology 154(6): S-714-S-715, 2018

Selective biliary cannulation techniques for endoscopic retrograde cholangiopancreatography procedures and prevention of post- endoscopic retrograde cholangiopancreatography pancreatitis. Expert Review of Gastroenterology and Hepatology 10(6): 709-722, 2016

A comparative evaluation of endoscopic retrograde cholangiopancreatography and the secretin-cholecystokinin test in the diagnosis of chronic pancreatitis: a multicentre study in 124 patients. Endoscopy 13(2): 64-67, 1981

Increased serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography induced pancreatitis with high accuracy. Gut 41(5): 690-695, 1997

Increased serum trypsinogen 2 and trypsin 2-1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography (ERCP)-induced pancreatitis with high accuracy. Gastrointestinal Endoscopy 47(6): 554-555, 1998

Rapid urinary trypsinogen-2 test in the early diagnosis of acute pancreatitis: a meta-analysis. Clinical Biochemistry 45(13-14): 1051-1056, 2012

Urinary trypsinogen-2 test strip for acute pancreatitis. Lancet (North American Edition) 347(9003): 729-731, 1996