Reactivation of inactive X chromosome in buccal smear of carcinoma of breast

Natekar, P.E.; Desouza, F.M.

Indian Journal of Human Genetics 14(1): 7-8

2008


ISSN/ISBN: 0971-6866
PMID: 20300284
Accession: 055386366

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Abstract
Buccal mucosal smears of 100 female patients of carcinoma of breast were compared with 100 controls matched accordingly. The frequency of Barr bodies was significantly lower in carcinoma of breast patients (menstruating and menopausal women) P < 0.001 when compared with controls indicating reactivation of the inactive X chromosome.