+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Recent advances and method development for drug target identification

Recent advances and method development for drug target identification

Trends in Pharmacological Sciences 31(2): 82-88

Although it is commonly recognized that most drugs cause inhibition or activation of function by physically binding to one or more gene products, the direct interactions of bioactive small molecules with specific gene products, or targets, is often not well characterized. From a therapeutic perspective, it is nevertheless essential to know a drug's binding partner(s) to understand the mechanism of action and anticipate possible side effects to avoid costly clinical failures. This knowledge is increasingly important as the prevalence of polypharmacy expands to include drugs that engage multiple targets. This review provides a succinct overview of several recent approaches that employ genetics, proteomics, expression profiling or bioinformatics procedures for the systematic characterization of the targets of bioactive compounds. The continuous improvement and advancement of existing technologies is critically discussed and we offer a perspective on the future of innovative emerging new generation technologies.

(PDF emailed within 0-6 h: $19.90)

Accession: 055397173

Download citation: RISBibTeXText

PMID: 20004028

DOI: 10.1016/j.tips.2009.11.002

Related references

A Review of Recent Advances and Research on Drug Target Identification Methods. Current Drug Metabolism: -, 2018

Recent Advances in the System Biology-based Target Identification and Drug Discovery. Current Topics in Medicinal Chemistry 18(20): 1737-1744, 2018

Recent advances in target identification of bioactive natural products. Bioscience, Biotechnology, and Biochemistry 83(1): 1-9, 2018

Recent advances in target characterization and identification by photoaffinity probes. Molecules 18(9): 10425-10451, 2014

The face of future hepatitis C antiviral drug development: recent biological and virologic advances and their translation to drug development and clinical practice. Journal of Hepatology 44(2): 411-421, 2005

Recent Advances on the Network Models in Target-based Drug Discovery. Current Topics in Medicinal Chemistry: -, 2018

The HIV-1 capsid protein as a drug target: recent advances and future prospects. Current Protein & Peptide Science 14(8): 658-668, 2014

Recent advances in the machine learning-based drug-target interaction prediction. Current Drug Metabolism: -, 2018

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action. Medicinal Research Reviews 37(6): 1492-1517, 2017

Recent advances in antituberculous drug development and novel drug targets. Expert Review of Respiratory Medicine 2(4): 455-471, 2008

Recent advances towards identification of new drug targets for Mycobacterium tuberculosis. Expert Opinion on Therapeutic Targets 8(2): 79-93, 2004

Recent advances for identification of new scaffolds and drug targets for Mycobacterium tuberculosis. Iubmb Life: -, 2018

Recent Advances in the Development of Small-Molecular Inhibitors Target HIV Integrase-LEDGF/p75 Interaction. Mini Reviews in Medicinal Chemistry 15(14): 1195-1208, 2016

Advances with phospholipid signalling as a target for anticancer drug development. Acta Biochimica Polonica 42(4): 395-403, 1995

Recent advances in antimalarial drug development. Medicinal Research Reviews 27(1): 65-107, 2006