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Recent advances and novel agents for gastrointestinal stromal tumor (GIST)

Recent advances and novel agents for gastrointestinal stromal tumor (GIST)

Journal of Hematology & Oncology 5: 21-21

The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs)marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma,schwannoma, hemangioma, leiomyoma, and leiomyosarcoma are typically CD117-negative.GIST research and clinical care now represent a paradigm of translating discoveries in themolecular pathogenesis of cancer into highly effective targeted therapies that selectivelyinhibit etiologic "driver" pathways, leading to dramatically improved clinical outcomes. Aseries of investigations and trials are underway to develop novel and effective ways to treatpatients with GIST. In this review, we discuss the highlights of recent advances and novelagents for GIST therapy.

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Accession: 055397177

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PMID: 22569033

DOI: 10.1186/1756-8722-5-21

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