+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Recent advances in cardiovascular proteomics

Recent advances in cardiovascular proteomics

Journal of Proteomics 81: 3-14

Cardiovascular diseases (CVDs) are the major source of global morbidity and death and more people die annually from CVDs than from any other cause. These diseases can occur quickly, as seen in acute myocardial infarction (AMI), or progress slowly over years as with chronic heart failure. Advances in mass spectrometry detection and analysis, together with improved isolation and enrichment techniques allowing for the separation of organelles and membrane proteins, now allow for the indepth analysis of the cardiac proteome. Here we outline current insights that have been provided through cardiovascular proteomics, and discuss studies that have developed innovative technologies which permit the examination of the protein complement in specific organelles including exosomes and secreted proteins. We highlight these foundational studies and illustrate how they are providing the technologies and tools which are now being applied to further study cardiovascular disease; provide new diagnostic markers and potentially new methods of cardiac patient management with identification of novel drug targets. This article is part of a Special Issue entitled: From protein structures to clinical applications.

(PDF emailed within 0-6 h: $19.90)

Accession: 055397532

Download citation: RISBibTeXText

PMID: 23153792

DOI: 10.1016/j.jprot.2012.10.026

Related references

Recent advances in platelet proteomics. Expert Review of Proteomics 9(4): 451-466, 2013

Recent advances in proteomics of cereals. Biotechnology and Genetic Engineering Reviews 32(1-2): 1-17, 2017

Recent advances in membrane proteomics. Proteomics 8(19): 3919, 2008

Recent technical advances in proteomics. F1000research 8, 2019

Recent advances in capillary separations for proteomics. Electrophoresis 25(23-24): 3913-3926, 2004

Recent advances in microarray technologies for proteomics. Chemistry and Biology 20(5): 685-699, 2013

Recent advances in proteomics: towards the human proteome. Biomedical Chromatography 28(6): 848-857, 2015

Recent advances in blood-related proteomics. Proteomics 5(12): 3019-3034, 2005

Nano-LC in proteomics: recent advances and approaches. Bioanalysis 7(14): 1799-1815, 2016

Diagnosis and treatment of cardiovascular diseases.Recent advances.Recent advances in the treatment of hypertension. Nihon Naika Gakkai Zasshi 84(3): 342-346, 1995

Cardiovascular proteomics in the era of big data: experimental and computational advances. Clinical Proteomics 13: 23, 2016

Recent advances in plant cell wall proteomics. Proteomics 8(4): 893-908, 2008

Recent advances in clinical proteomics using mass spectrometry. Bioanalysis 2(9): 1609-1615, 2011

Cartilage proteomics: Challenges, solutions and recent advances. Proteomics. Clinical Applications 2(2): 251-263, 2008

Recent advances in proteomics and cancer biomarker discovery. Clinical Medicine. Oncology 2: 63-72, 2008