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Recent advances in cloning herpesviral genomes as infectious bacterial artificial chromosomes



Recent advances in cloning herpesviral genomes as infectious bacterial artificial chromosomes



Cell Cycle 10(3): 434-440



Herpesviruses are common but important pathogens in humans and animals. These viruses have large complex genomes encoding genes with diverse functions in different phases of their life cycle and associated diseases. In the last decade, genomes of herpesviruses cloned as infectious bacterial artificial chromosomes (BACs) have become powerful tools for delineating the functions of viral genes and understanding the pathogenesis of their associated diseases. Here we review the history of herpesviral genetics and recent advances in methods for cloning herpesviral genomes as infectious BACs.

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Accession: 055397602

Download citation: RISBibTeXText

PMID: 21245660

DOI: 10.4161/cc.10.3.14708


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