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Recent advances in malaria drug discovery



Recent advances in malaria drug discovery



Bioorganic and Medicinal Chemistry Letters 23(10): 2829-2843



This digest covers some of the most relevant progress in malaria drug discovery published between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such drugs can target the blood stage of the disease to alleviate the symptoms, the liver stage to prevent relapses, and the transmission stage to protect other humans. The pipeline for the blood stage is becoming robust, but this should not be a source of complacency, as the current therapies set a high standard. Drug discovery efforts directed towards the liver and transmission stages are in their infancy but are receiving increasing attention as targeting these stages could be instrumental in eradicating malaria.

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Accession: 055398056

Download citation: RISBibTeXText

PMID: 23587422

DOI: 10.1016/j.bmcl.2013.03.067


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