+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Recent advances in sunlight-induced carcinogenesis using the Xiphophorus melanoma model

Recent advances in sunlight-induced carcinogenesis using the Xiphophorus melanoma model

Comparative Biochemistry and Physiology. Toxicology and Pharmacology 155(1): 64-70

Unlike breast and prostate cancers, the nature and sequence of critical genetic and epigenetic events involved in the initiation and progression of melanoma are not well understood. A contributing factor to this dilemma, especially given our current understanding of the importance of UV light in melanoma etiology, is the lack of quality UV-inducible melanoma animal models. In this study we elaborate on the capability of UV light to induce cutaneous malignant melanomas (CMM) in Xiphophorus fishes, which were previously found to develop melanomas after acute neonatal UVB irradiation. In two separate tumorigenesis experiments, we exposed adult Xiphophorus hybrids to either acute UVB irradiations (5 consecutive daily treatments) or chronic solar irradiations (continuous UVA/UVB treatment for 9 months). Acute adult UVB irradiation resulted in the significant induction of melanomas, and moreover, this induction rate is equivalent to that of animals exposed to acute neonatal UVB irradiation. This study represents the first evidence that acute adult UVB irradiation, in the absence of any early life exposures, induces CMM. Similar to the findings conducted on other divergent melanoma models, including HGF/SF transgenic mice and Monodelphis domestica, prolonged chronic solar UV was not a factor in melanomagenesis.

(PDF emailed within 0-6 h: $19.90)

Accession: 055398685

Download citation: RISBibTeXText

PMID: 21457786

DOI: 10.1016/j.cbpc.2011.03.007

Related references

Nonmammalian models for sunlight carcinogenesis: Genetic analysis of melanoma formation in Xiphophorus hybrid fish. Photochemistry and Photobiology 64(3): 440-448, 1996

The etiology of sunlight-induced melanoma in Xiphophorus hybrid fish. Molecular Carcinogenesis 46(8): 679-684, 2007

Genetic analysis of UV-B induced melanoma formation in interspecies genetic hybrids of Xiphophorus fish A model for environmental UV carcinogenesis. Photochemistry & Photobiology 61(5 SUPPL ): 7S-8S, 1995

Attempts at analyzing the initiation of the initial processes of carcinogenesis based on the Xiphophorus melanoma model. Archiv für Geschwulstforschung 60(4): 249-263, 1990

A putative marker for human melanoma. A monoclonal antibody derived from the melanoma gene in the Xiphophorus melanoma model. American Journal of Pathology 143(3): 656-662, 1993

Attempts to analyze the initiation of initiating processes of carcinogenesis in the xiphophorus melanoma models. Archiv fuer Geschwulstforschung 60(4): 249-263, 1990

Novel antigenic in determinant in human melanoma derived from studies on the xiphophorus fish melanoma model. Pigment Cell Research 6(4 PART 2): 313, 1993

Novel antigenic determinant in human melanoma derived from studies on the Xiphophorus fish melanoma model. Clinical & Investigative Medicine 16(4 SUPPL ): B92, 1993

The xiphophorus model dna hypomethylation in carcinogenesis. European Journal of Cell Biology Supplement (12): 32, 1985

Recent advances in cutaneous melanoma: towards a molecular model and targeted treatment. Australasian Journal of Dermatology 54(3): 163-172, 2014

Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicology and Applied Pharmacology 172(3): 249-261, 2001

Culture of embryos and cells from platyfish xiphophorus maculatus and swordtails xiphophorus helleri for carcinogenicity testing and studies on melanoma formation. National Cancer Institute Monograph : 179-184, 1984

From Mendelian to molecular genetics: the Xiphophorus melanoma model. Trends in Genetics 22(12): 654-661, 2006

Genetic analysis of susceptibility to spontaneous and UV-induced carcinogenesis in Xiphophorus hybrid fish. Marine Biotechnology 3(Supplement 1): S24-S36, 2004

Proteomic analyses of the Xiphophorus Gordon-Kosswig melanoma model. Comparative Biochemistry and Physiology. Toxicology and Pharmacology 155(1): 81-88, 2012