+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Recent advances in synthesis and surface modification of lanthanide-doped upconversion nanoparticles for biomedical applications

Recent advances in synthesis and surface modification of lanthanide-doped upconversion nanoparticles for biomedical applications

Biotechnology Advances 30(6): 1551-1561

Lanthanide (Ln)-doped upconversion nanoparticles (UCNPs) with appropriate surface modification can be used for a wide range of biomedical applications such as bio-detection, cancer therapy, bio-labeling, fluorescence imaging, magnetic resonance imaging and drug delivery. The upconversion phenomenon exhibited by Ln-doped UCNPs renders them tremendous advantages in biological applications over other types of fluorescent materials (e.g., organic dyes, fluorescent proteins, gold nanoparticles, quantum dots, and luminescent transition metal complexes) for: (i) enhanced tissue penetration depths achieved by near-infrared (NIR) excitation; (ii) improved stability against photobleaching, photoblinking and photochemical degradation; (iii) non-photodamaging to DNA/RNA due to lower excitation light energy; (iv) lower cytotoxicity; and (v) higher detection sensitivity. Ln-doped UCNPs are therefore attracting increasing attentions in recent years. In this review, we present recent advances in the synthesis of Ln-doped UCNPs and their surface modification, as well as their emerging applications in biomedicine. The future prospects of Ln-doped UCNPs for biomedical applications are also discussed.

(PDF emailed within 0-6 h: $19.90)

Accession: 055398703

Download citation: RISBibTeXText

PMID: 22561011

DOI: 10.1016/j.biotechadv.2012.04.009

Related references

Recent advances in lanthanide-doped upconversion nanomaterials: synthesis, nanostructures and surface modification. Nanoscale 5(23): 11512-11525, 2013

Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. Chemical Society Reviews 38(4): 976-989, 2009

Upconversion nanoparticles: synthesis, surface modification and biological applications. Nanomedicine 7(6): 710-729, 2012

Controlled optical characteristics of lanthanide doped upconversion nanoparticles for emerging applications. Dalton Transactions 46(48): 16729-16737, 2017

Biomimetic surface engineering of lanthanide-doped upconversion nanoparticles as versatile bioprobes. Angewandte Chemie 51(25): 6121-6125, 2012

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications. Artificial Cells, Nanomedicine, and Biotechnology 45(4): 788-799, 2017

Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomedicine 2(1): 23-39, 2007

Color-coded multilayer photopatterned microstructures using lanthanide (III) ion co-doped NaYF4 nanoparticles with upconversion luminescence for possible applications in security. Nanotechnology 20(18): 185301, 2009

Synthesis of colour tunable lanthanide-ion doped NaYF4 upconversion nanoparticles by controlling temperature. Chemical Communications 46(22): 3908-3910, 2010

Multicolor output and shape controlled synthesis of lanthanide-ion doped fluorides upconversion nanoparticles. Dalton Transactions 40(13): 3305-3314, 2011

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications. Journal of Visualized Experiments 2018(129), 2018

Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy. Biomaterials Science 6(4): 877-884, 2018

Ultrasmall iron oxide nanoparticles: synthesis, surface modification, assembly, and biomedical applications. Drug Discovery Today 2019, 2019

Lanthanide Doped Near Infrared Active Upconversion Nanophosphors: Fundamental Concepts, Synthesis Strategies, and Technological Applications. Small 14(37): E1801304, 2018

Superparamagnetic iron oxide nanoparticles (SPIONs): synthesis and surface modification techniques for use with MRI and other biomedical applications. Current Pharmaceutical Design 19(3): 493-509, 2013