+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Recent advances in the pathogenesis of rheumatoid arthritis



Recent advances in the pathogenesis of rheumatoid arthritis



Clinical Calcium 19(3): 303-309



Rheumatoid arthritis is a chronic inflammatory polyarthritis and is thought to be an autoimmune, multifactorial and polygenic disease. Recent studies have uncovered many important players in the pathogenesis of rheumatoid arthritis. Immune cells, mesenchymal cells, and bone-associated cells are all involved in the pathogenesis and are closely related with each other. The genetic predisposition to rheumatoid arthritis is confirmed by many family studies and HLA association studies. Genome-wide disease association studies identified genetic risk foci, such as HLA-DRB1, PADI4, and PTPN22. In addition to the genetic contribution, environmental factors are increasingly recognized. Many studies revealed that smoking is a risk factor for rheumatoid arthritis. The role of B and T lymphocytes in the pathogenesis has been reevaluated by biological agents such as rituximab (anti-CD20 antibody) and abatacept (CTLA4-Ig) , respectively. T cells in rheumatoid arthritis have been shown to have the altered level of surface molecules such as CD28, cytokine pattern shift, and shortened telomere lengths. Moreover, telomere loss is recognized not only in lymphocytes but also in hematopoietic progenitor cells. This phenomenon and the presence of rheumatoid-specific anti-citrullinated protein antibodies are reported to be associated with HLA haplotypes.

(PDF emailed within 1 workday: $29.90)

Accession: 055399146

Download citation: RISBibTeXText

PMID: 19252239


Related references

Recent advances in the pathogenesis, prediction, and management of rheumatoid arthritis-associated interstitial lung disease. Current Opinion in Rheumatology 29(3): 254-259, 2017

Recent Advances in the Rehabilitation of Rheumatoid Arthritis; Rheumatoid Factor. Maryland State Medical Journal 14: 117-119, 1965

Advances in pathogenesis of anemia in rheumatoid arthritis. Postepy Higieny i Medycyny Doswiadczalnej 48(6): 745-752, 1994

Advances in immunology and rheumatoid arthritis pathogenesis. Reumatismo 56(1 Suppl 1): 9-20, 2004

Recent advances in rheumatology: biological agents for the treatment of rheumatoid arthritis, the progression of psoriatic arthritis, autoantibodies in systemic lupus erythematosus. Clinical and Experimental Dermatology 30(2): 201-204, 2005

Recent advances in rheumatoid arthritis. New York State Journal of Medicine 57(21): 3489-3499, 1957

Recent advances in rheumatoid arthritis. Postgraduate Medical Journal 86(1014): 243-250, 2010

Recent advances in the pathogenesis of reactive arthritis. Immunology Today 17(4): 160-163, 1996

The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane and I. Sudoł-Szopińska, K. Zaniewicz-Kaniewska, A. Warczyńska, G. Matuszewska, F. Saied, W. Kunisz The pathogenesis of rheumatoid arthritis in radiological studies. Part II: Imaging studies in rheumatoid arthritis. Journal of Ultrasonography 12(51): 503-505, 2012

Recent advances in the treatment of rheumatoid arthritis. Clinical Cornerstone 2(2): 38-50, 2000

Recent advances in the genetics of rheumatoid arthritis. Current Rheumatology Reports 8(5): 394-400, 2006

Recent advances in the treatment of rheumatoid arthritis. Postgraduate Medical Journal 26(298): 447-451, 1950

Recent advances in the treatment of rheumatoid arthritis. Current Opinion in Rheumatology 30(3): 231-237, 2018

Recent advances in the genetics of rheumatoid arthritis. Current Opinion in Rheumatology 22(2): 109-118, 2010

Recent Advances in the Rehabilitation of Rheumatoid Arthritis. Maryland State Medical Journal 14: 81-82, 1965