+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Recent trends in hormone therapy utilization and breast cancer incidence rates in the high incidence population of Marin County, California

Recent trends in hormone therapy utilization and breast cancer incidence rates in the high incidence population of Marin County, California

Bmc Public Health 10: 228

Recent declines in invasive breast cancer have been reported in the US, with many studies linking these declines to reductions in the use of combination estrogen/progestin hormone therapy (EPHT). We evaluated the changing use of postmenopausal hormone therapy, mammography screening rates, and the decline in breast cancer incidence specifically for Marin County, California, a population with historically elevated breast cancer incidence rates. The Marin Women's Study (MWS) is a community-based, prospective cohort study launched in 2006 to monitor changes in breast cancer, breast density, and personal and biologic risk factors among women living in Marin County. The MWS enrolled 1,833 women following routine screening mammography between October 2006 and July 2007. Participants completed a self-administered questionnaire that included items regarding historical hormone therapy regimen (estrogen only, progesterone only, EPHT), age of first and last use, total years of use, and reason(s) for stopping, as well as information regarding complementary hormone use. Questionnaire items were analyzed for 1,083 non-Hispanic white participants ages 50 and over. Breast cancer incidence rates were assessed overall and by tumor histology and estrogen receptor (ER) status for the years 1990-2007 using data from the Northern California Surveillance, Epidemiology and End Results (SEER) cancer registry. Prevalence of EPHT use among non-Hispanic white women ages 50 and over declined sharply from 21.2% in 1998 to 6.7% by 2006-07. Estrogen only use declined from 26.9% in 1998 to 22.4% by 2006-07. Invasive breast cancer incidence rates declined 33.4% between 2001 and 2004, with drops most pronounced for ER+ cancers. These rate reductions corresponded to declines of about 50 cases per year, consistent with population attributable fraction estimates for EPHT-related breast cancer. Self-reported screening mammography rates did not change during this period. Use of alternative or complementary agents did not differ significantly between ever and never hormone users. Of women who reported stopping EPHT in the past 5 years, 60% cited "health risks" or "news reports" as their primary reasons for quitting. A dramatic reduction in EPHT use was followed temporally by a significant reduction in invasive and ER+ breast cancer rates among women living in Marin County, California.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055403014

Download citation: RISBibTeXText

PMID: 20433756

DOI: 10.1186/1471-2458-10-228

Related references

Breast cancer incidence and mortality trends in an affluent population: Marin County, California, USA, 1990-1999. Breast Cancer Research 4(6): R13, 2002

Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort. Breast Cancer Research 12(1): R4, 2010

Recent declines in hormone therapy utilization and breast cancer incidence: clinical and population-based evidence. Journal of Clinical Oncology 24(33): E49-E50, 2006

Breast cancer incidence in Marin county, California A canary in the mine-shaft?. American Journal of Epidemiology 155(11 Suppl.): S107, June 1, 2002

Assessing breast cancer risk models in Marin County, a population with high rates of delayed childbirth. Clinical Breast Cancer 14(3): 212-220.E1, 2015

Breast cancer in Asian Americans in California, 1988-2013: increasing incidence trends and recent data on breast cancer subtypes. Breast Cancer Research and Treatment 164(1): 139-147, 2017

Recent trends in U.S. breast cancer incidence, survival, and mortality rates. Journal of the National Cancer Institute 88(21): 1571-1579, 1996

Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women. Breast Cancer Research 9(3): R28, 2007

Recent trends in breast cancer incidence among 6 Asian groups in the Greater Bay Area of Northern California. International Journal of Cancer 120(6): 1324-1329, 2006

Recent trends in breast cancer incidence rates in the Loire-Atlantique, France: a decline since 2003. Cancer Epidemiology 34(3): 238-243, 2010

Increasing incidence and constant mortality rates of breast cancer: time trends in Stockholm County 1961-1973. Breast Cancer Research and Treatment 4(3): 233-243, 1984

Prostate Cancer: Trends in Mortality and Stage-Specific Incidence Rates by Racial/Ethnic Group in Los Angeles County, California (United States). Cancer Causes & Control 6(6): 492-498, 1995

Prostate cancer: Trends in mortality and stage-specific incidence rates by racial/ethnic group in Los Angeles County, California (United States). Cancer Causes and Control 6(6): 492-498, 1995

Recent trends in breast cancer incidence in US white women by county-level urban/rural and poverty status. Bmc Medicine 7: 31, 2009

Trends in breast cancer incidence associated with reductions in the use of hormone replacement therapy. Cancer Epidemiology 35(1): 11-16, 2011