+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Recurrence in operated patients with laryngeal squamous cell carcinoma



Recurrence in operated patients with laryngeal squamous cell carcinoma



Otolaryngologia Polska 63(5): 419-428



The aim of the present study was to investigate the recurrence prevalence in patients with laryngeal squamous cell carcinoma (LSCC) underwent surgery as primary treatment. The assessed group consisted of 148 patients with operable LSCC underwent surgery as primary treatment between 1999-2002. Surgery was performed in all cases. Total laryngectomy was performed in 107 (72.3%) patients and laser endoscopic tumor resection was performed in 41 (27.7%) patients. Local recurrence occurred in 18 (12.2%) patients, nodal recurrence in 12 (8.1%) and both and/or remote metastases in 6 (4%) patients. Altogether, recurrence was present in 36 (24.3%) patients and 111 (75.7%) patients had no symptoms of recurrence. Recurrence prevalence in 3-year follow-up--prevalence of recurrence significantly increased with tumor's T feature (p=0.04), N feature (p=0.03), progression of clinical stage (p=0.008) and histological malignancy G stage (p=0.01). Recurrence prevalence in 5-year follow-up--prevalence of recurrence significantly increased with tumor's T feature (p=0.02), N feature (p=0.01), progression of clinical stage (p=0.003) and histological malignancy G stage (p=0.002). Tumors localized in glottic area had less recurrences than those localized in supraglottic area (p=0.05). There were no significant dependence between recurrence type (local or nodal) and tumor's clinicopathological features. Multiple factor analysis with logistic regression model did not revealed simultaneous influence of many variables on recurrence's presence and type. Using multiple factor analysis with Cox's regression model it was proved that recurrence presence (p<0.00001) is a significant independent prognostic factor in the analyzed group of patients with laryngeal carcinoma in 3-year follow-up. Recurrence prevalence depends on localization, systemic progression stage, clinical progression stage, cervical lymph nodes state and histological malignancy stage of tumor. Patients with local recurrence have statistically significantly worse prognosis than patients with no recurrence. Recurrence presence is significant independent prognostic factor in 3-year follow-up.

(PDF emailed within 0-6 h: $19.90)

Accession: 055417536

Download citation: RISBibTeXText

PMID: 20169907

DOI: 10.1016/S0030-6657(09)70154-4



Related references

Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology 139(9): 1499-1506, 2013

Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification. Head & Neck 30(7): 939-945, 2008

MicroRNA-34c-5p is related to recurrence in laryngeal squamous cell carcinoma. Laryngoscope 125(9): E306-E312, 2015

Squamous cell carcinoma-antigen messenger RNA level in peripheral blood predicts recurrence after resection in patients with esophageal squamous cell carcinoma. Surgery 139(5): 678-685, 2006

DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45(6): 497-501, 2011

The prognostic value of squamous cell carcinoma antigen for predicting tumor recurrence in cervical squamous cell carcinoma patients. Obstetrics & Gynecology Science 58(5): 368-376, 2015

The immunohistochemical peptidergic expression of leptin is associated with recurrence of malignancy in laryngeal squamous cell carcinoma. Acta Otorhinolaryngologica Italica 35(1): 15-22, 2015

Intraoperative opioids use for laryngeal squamous cell carcinoma surgery and recurrence: a retrospective study. Journal of Clinical Anesthesia 27(8): 672-679, 2016

Expression of p27 and PTEN and clinical characteristics in early laryngeal squamous cell carcinoma and their correlation with recurrence. International Journal of Clinical and Experimental Pathology 8(5): 5715-5720, 2016

CD105-assessed micro-vessel density is associated with malignancy recurrence in laryngeal squamous cell carcinoma. European Journal of Surgical Oncology 32(10): 1149-1153, 2006

Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma. 2012

Thymidine labeling index in laryngeal squamous cell carcinoma in correlation with pTNM, age, histological grade and recurrence. Orl; Journal for Oto-Rhino-Laryngology and Its Related Specialties 64(4): 257-262, 2002

Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma. Tumour Biology 35(1): 623-629, 2014

Over-expression of p53, p21 and Cdc2 in histologically negative surgical margins is correlated with local recurrence of laryngeal squamous cell carcinoma. International Journal of Clinical and Experimental Pathology 7(7): 4295-4302, 2015

Prognostic factors for post-recurrence survival in esophageal squamous cell carcinoma patients with recurrence after resection. Journal of Gastrointestinal Surgery 15(4): 558-565, 2011