+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Recurrence of primary biliary cirrhosis and development of autoimmune hepatitis after liver transplant: A blind histologic study



Recurrence of primary biliary cirrhosis and development of autoimmune hepatitis after liver transplant: A blind histologic study



Hepatology Research 39(6): 577-584



This long-term study aimed to evaluate recurrence and evolution of primary biliary cirrhosis (PBC) after orthotopic liver transplantation (OLT). We reviewed "blindly" allograft biopsy specimens of women who underwent transplantation for PBC (n = 84), and women who received a transplant for chronic hepatitis C virus infection (CHCV ) (n = 108). All needle liver biopsy specimens obtained more than 6 months post-OLT were examined, including 83 specimens from 44 PBC patients and 152 specimens from 58 CHCV patients. Granulomatous destructive cholangitis was found in five biopsies from four PBC patients (P = 0.0048). Non-necrotizing epithelioid cell granulomas were present in four biopsies from four PBC patients, and in two biopsies from one CHCV patient. Piecemeal necrosis (P = 0.0002), lobular necroinflammatory activity (P < 0.0001), steatosis (P < 0.0001) and fibrosis (P < 0.0001) were more prevalent in CHCV patients than PBC patients. Four PBC patients developed histologic evidence of autoimmune hepatitis (AIH), at a mean time of 3.66 years post-OLT. One of these patients had histologic features of AIH/PBC overlap syndrome. All four patients developed bridging fibrosis (n = 2) or cirrhosis (n = 2). No other PBC patient had evidence of cirrhosis after OLT. Histologic findings indicative of recurrent PBC were present in 15.9% of the PBC patients undergoing biopsy in this series. However, this group of patients did not suffer significant bile duct loss or fibrosis, as compared to the control group, suggesting that recurrent PBC is a mild or slowly progressive disease. Histologic evidence of AIH was observed in allograft biopsies of some PBC patients.

(PDF emailed within 0-6 h: $19.90)

Accession: 055417889

Download citation: RISBibTeXText

PMID: 19207586

DOI: 10.1111/j.1872-034X.2008.00483.x


Related references

Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. Liver Transplantation 15 Suppl 2: S25-S34, 2010

Recurrence of primary biliary cirrhosis and autoimmune hepatitis in orthotopic liver transplantation. Modern Pathology 8(1): 133A, 1995

Recurrence of autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis after liver transplantation. Acta Gastro-Enterologica Belgica 68(3): 331-336, 2005

Concurrent de novo autoimmune hepatitis and recurrence of primary biliary cirrhosis post-liver transplantation. Liver Transplantation 7(5): 461-465, 2001

Development of autoimmune hepatitis following liver transplantation for primary biliary cirrhosis. Hepatology 30(1): 53-57, 1999

Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: a retrospective study of 115 cases of autoimmune liver disease. Gastroenterologie Clinique et Biologique 31(1): 17-25, 2007

Flare-up of autoimmune hepatitis after delivery in a patient with primary biliary cirrhosis: postpartum overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis. Digestive Diseases and Sciences 50(1): 201-206, 2005

"Overlap" syndromes. Autoimmune hepatitis--primary biliary liver cirrhosis; autoimmune hepatitis--primary sclerosing cholangitis. Presse Medicale 30(1): 25-27, 2001

The usefulness of IgG and IgM immunostaining of periportal inflammatory cells (plasma cells and lymphocytes) for the distinction of autoimmune hepatitis and primary biliary cirrhosis and their staining pattern in autoimmune hepatitis-primary biliary cirrhosis overlap syndrome. American Journal of Clinical Pathology 133(3): 430-437, 2010

Recurrence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. Liver Transplantation and Surgery 1(5 Suppl 1): 109-115, 1995

Living donor liver transplantation for autoimmune hepatitis and autoimmune hepatitis-primary biliary cirrhosis overlap syndrome. 2012

Histologic evidence for recurrence of primary biliary cirrhosis pbc following liver transplantation ltx. Gastroenterology 102(4 PART 2): A778, 1992

Histologic similarity of post liver transplant liver biopsies in primary biliary cirrhosis and other diseases. Gastroenterology 110(4 SUPPL ): A1166, 1996

Autoimmune diseases of the liver, autoimmune hepatitis and primary biliary cirrhosis: Unfinished business. Hepatology Research 37 Suppl 3: S357-S364, 2007