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Recurrent giant chalazia in hyperimmunoglobulin E (Job's) syndrome

, : Recurrent giant chalazia in hyperimmunoglobulin E (Job's) syndrome. International Ophthalmology 29(5): 415-417

Hyperimmunoglobulinemia E (Job's) syndrome is a rare autosomal dominant disorder appearing early in life with recurrent skin and pulmonary infections, characterized by markedly increased serum immunoglobulin E (IgE) levels. We describe a 50-year-old man with a 4-year history of recurrent, multiple giant chalazia in all eyelids. Medications and surgical intervention had produced only transient improvement. The patient had also had pulmonary and scalp infection. Laboratory tests disclosed elevated serum IgE (>1,000 IU/ml) and eosinophilia. As a result, based on the patient's history and clinical and laboratory findings, a diagnosis of Job's syndrome was made. Even though rarely, recurrent multiple giant chalazia may occur as an ophthalmic feature of Job's syndrome. Hyperimmunoglobulinemia E syndrome should be suspected in any case of recurrent giant chalazia, regardless of the patient's age. Measurement of serum IgE and eosinophils, along with internal evaluation, is essential to establish a proper diagnosis.

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Accession: 055419534

PMID: 18528638

DOI: 10.1007/s10792-008-9238-y

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Related references

Crama, N.; Toolens, A.M.P.; van der Meer, J.W.M.; Cruysberg, J.R.M., 2004: Giant chalazia in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. To report the occurrence of recurrent multiple giant chalazia in the hyperimmunoglobulin E syndrome (hyper-IgE syndrome or Job syndrome). Two patients with hyperimmunoglobulinemia E (>500 IU/ml) had ophthalmologic examination and surgical treat...

Destafeno, J.J.; Kodsi, S.R.; Primack, J.D., 2005: Recurrent Staphylococcus aureus chalazia in hyperimmunoglobulinemia E (Job's) syndrome. PURPOSE: To report a case of recurrent Staphylococcus aureus chalazia in a patient with hyperimmunoglobulinemia E syndrome (Job's Syndrome). DESIGN: Case report. METHODS: Three separate surgical incisions and curettages of multiple, recurrent...

Lebranchu Y.; Blanchard P.; Lorette G.; Demont F.; Marchand S.; Bonnard C.; Grenier B., 1986: Hyperimmunoglobulin e syndrome with recurrent infections buckley syndrome association with genu varum. Semaine des Hopitaux 62(44): 3563-3566

Van Eendenburg, J.P.; Smitt, J.H.; Weening, R.S., 1991: Hyperimmunoglobulin E recurrent infection (Job's) syndrome. British Journal of Dermatology 125(4): 397-397

Kanoh, T., 1998: Job's syndrome (hyperimmunoglobulin E and recurrent infection syndrome). Ryoikibetsu Shokogun Shirizu: 261-263

Dreskin, S.C.; Gallin, J.I., 1987: Evolution of the hyperimmunoglobulin E and recurrent infection (HIE, JOB's) syndrome in a young girl. The hyperimmunoglobulin E and recurrent infection syndrome is difficult to diagnose in children with markedly elevated IgE and recurrent superficial Staphylococcus aureus infections who have not presented with a severe infection. The patient, the...

Donabedian, H.; Alling, D.W.; Gallin, J.I., 1982: Levamisole is inferior to placebo in the hyperimmunoglobulin E recurrent-infection (Job's) syndrome. New England Journal of Medicine 307(5): 290-292

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