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Reductive N-alkylation of nitroarenes: a green approach for the N-alkylation of natural products



Reductive N-alkylation of nitroarenes: a green approach for the N-alkylation of natural products



Journal of Organic Chemistry 77(10): 4578-4585



A simple, mild, cost-effective, and green approach for the reductive mono-N-alkylation of nitroarenes has been developed. HOAc/Zn are utilized as the reducing system together with a carbonyl compound as an alkyl source in methanol. Excellent yields were obtained with stoichiometric control of mono- over dialkylated products. Application to five complex natural products demonstrated the practical utility of the method.

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Accession: 055434255

Download citation: RISBibTeXText

PMID: 22482705

DOI: 10.1021/jo300303d


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