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Regioselective and guided C-H activation of 4-nitropyrazoles

, : Regioselective and guided C-H activation of 4-nitropyrazoles. Journal of Organic Chemistry 79(7): 2906-2915

A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H-pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevant pyrazole scaffold. The scope and limitations of the methodology were studied.

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Accession: 055445541

PMID: 24601649

DOI: 10.1021/jo4025418

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