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Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines



Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines



Organic Letters 13(8): 2030-2033



Bimolecular cobalt-catalyzed [2 + 2 + 2] cycloadditions between yne-ynamides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts groups are efficiently deprotected in an orthogonal fashion.

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Accession: 055445588

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PMID: 21413688

DOI: 10.1021/ol200417p



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