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Regioselective hydroformylation of allylic alcohols

Organic Letters 13(10): 2686-2689
Regioselective hydroformylation of allylic alcohols
A highly regioselective hydroformylation of allylic alcohols is reported toward the synthesis of β-hydroxy-acid and aldehyde products. The selectivity is achieved through the use of a ligand that reversibly binds to alcohols in situ, allowing for a directed hydroformylation to occur. The application to trisubstituted olefins was also demonstrated, which yields a single diastereomer product consistent with a stereospecific addition of CO and hydrogen.

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Accession: 055445677

PMID: 21504208

DOI: 10.1021/ol200782d

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