+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Regression of optic disc neovascularization in patients with Behçet's uveoretinitis after infliximab therapy

Regression of optic disc neovascularization in patients with Behçet's uveoretinitis after infliximab therapy

Journal of Ocular Pharmacology and Therapeutics 26(6): 627-630

Optic disc neovascularization (NVD) in patients with Behçet's uveoretinitis is a relatively uncommon but severe complication that lacks standardized treatments. We report 2 cases of Behçet's uveoretinitis that achieved partial regression of NVD after infliximab therapy. Intravenous infliximab infusions were administrated to 2 immunosuppressive therapy-resistant Behçet's uveoretinitis patients with severe NVD accompanied by vitreous hemorrhage (both eyes in case 1 and the left eye in case 2 ). Best-corrected visual acuity, funduscopic findings, and fluorescein angiography were evaluated before and after the treatments. After being switched to infliximab therapy, NVD in both cases stopped developing and regressed partially, as confirmed by fluorescein angiography and resolution of vitreous hemorrhage, which led to an improvement of the best-corrected visual acuity. Results suggest that infliximab administration might be an effective treatment in NVD patients with Behçet's uveoretinitis.

(PDF emailed within 0-6 h: $19.90)

Accession: 055446966

Download citation: RISBibTeXText

PMID: 21043804

DOI: 10.1089/jop.2010.0031

Related references

Regression of Optic Disc Neovascularization (NVD) in a Patient with Behçet's Disease Treated with Oral Corticosteroids and Adalimumab (ADA). Klinische Monatsblatter für Augenheilkunde 2019, 2019

Neovascularization of the optic disc in Behçet's disease. Japanese Journal of Ophthalmology 50(3): 256-265, 2006

Optic disc neovascularization in behcet's disease. Rinsho Ganka 45(1): 13-16, 1991

Regression of optic nerve head neovascularization in proliferative diabetic retinopathy after intravitreal triamcinolone. Regression of diabetic optic disc neovascularization after intravitreal triamcinolone. International Ophthalmology 25(2): 113-116, 2004

Effectiveness of infliximab in patients with Behçet syndrome and severe uveoretinitis. Report of five cases. Revista Medica de Chile 134(7): 875-882, 2006

Decreased ocular inflammatory attacks and background retinal and disc vascular leakage in patients with Behcet's disease on infliximab therapy. British Journal of Ophthalmology 95(9): 1245-1250, 2011

Spontaneous regression of optic disc neovascularization in Takayasu Arteritis. Eye (Basingstoke) 18(1): 86-88, January, 2004

Proliferative diabetic retinopathy. Regression of optic disc neovascularization after retinal photocoagulation. British Journal of Ophthalmology 54(8): 535-539, 1970

Multicenter study of infliximab for refractory uveoretinitis in Behçet disease. Archives of Ophthalmology 130(5): 592-598, 2012

Infliximab monotherapy versus infliximab and colchicine combination therapy in patients with Behçet's disease. Ocular Immunology and Inflammation 20(3): 193-197, 2012

Effects and safety of infliximab administration in refractory uveoretinitis with Behçet's disease. Nippon Ganka Gakkai Zasshi 114(2): 87-95, 2010

Regression of severe Behcet's eye disease with infliximab therapy; .first two cases treated in Pakistan. Jpma. Journal of the Pakistan Medical Association 62(11): 1242-1244, 2013

Severe vision loss with optic disc neovascularization after hemiretinal vascular obstruction associated with optic disc melanocytoma. JAMA Ophthalmology 133(10): E151502-E151502, 2016

Vascular shunt of the optic disc resembling neovascularization in a diabetic patient with optic disc drusen. European Journal of Ophthalmology 16(5): 764-766, 2006

Complete regression of retinal neovascularization after therapy with interferon alfa in Behçet's disease. British Journal of Ophthalmology 84(12): 1437-1438, 2001