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Regression of optic disc neovascularization in patients with Behçet's uveoretinitis after infliximab therapy



Regression of optic disc neovascularization in patients with Behçet's uveoretinitis after infliximab therapy



Journal of Ocular Pharmacology and Therapeutics 26(6): 627-630



Optic disc neovascularization (NVD) in patients with Behçet's uveoretinitis is a relatively uncommon but severe complication that lacks standardized treatments. We report 2 cases of Behçet's uveoretinitis that achieved partial regression of NVD after infliximab therapy. Intravenous infliximab infusions were administrated to 2 immunosuppressive therapy-resistant Behçet's uveoretinitis patients with severe NVD accompanied by vitreous hemorrhage (both eyes in case 1 and the left eye in case 2 ). Best-corrected visual acuity, funduscopic findings, and fluorescein angiography were evaluated before and after the treatments. After being switched to infliximab therapy, NVD in both cases stopped developing and regressed partially, as confirmed by fluorescein angiography and resolution of vitreous hemorrhage, which led to an improvement of the best-corrected visual acuity. Results suggest that infliximab administration might be an effective treatment in NVD patients with Behçet's uveoretinitis.

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Accession: 055446966

Download citation: RISBibTeXText

PMID: 21043804

DOI: 10.1089/jop.2010.0031


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