+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells



Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells



Biochimica et Biophysica Acta 1836(2): 304-320



Breast cancer angiogenesis is elicited and regulated by a number of factors including the Notch signaling. Notch receptors and ligands are expressed in breast cancer cells as well as in the stromal compartment and have been implicated in carcinogenesis. Signals exchanged between neighboring cells through the Notch pathway can amplify and consolidate molecular differences, which eventually dictate cell fates. Notch signaling and its crosstalk with many signaling pathways play an important role in breast cancer cell growth, migration, invasion, metastasis and angiogenesis, as well as cancer stem cell (CSC) self-renewal. Therefore, significant attention has been paid in recent years toward the development of clinically useful antagonists of Notch signaling. Better understanding of the structure, function and regulation of Notch intracellular signaling pathways, as well as its complex crosstalk with other oncogenic signals in breast cancer cells will be essential to ensure rational design and application of new combinatory therapeutic strategies. Novel opportunities have emerged from the discovery of Notch crosstalk with inflammatory and angiogenic cytokines and their links to CSCs. Combinatory treatments with drugs designed to prevent Notch oncogenic signal crosstalk may be advantageous over λ secretase inhibitors (GSIs) alone. In this review, we focus on the more recent advancements in our knowledge of aberrant Notch signaling contributing to breast cancer angiogenesis, as well as its crosstalk with other factors contributing to angiogenesis and CSCs.

(PDF emailed within 0-6 h: $19.90)

Accession: 055450006

Download citation: RISBibTeXText

PMID: 24183943

DOI: 10.1016/j.bbcan.2013.10.003


Related references

Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer. Breast Cancer Research 15(5): 316-316, 2014

Upregulated SCUBE2 expression in breast cancer stem cells enhances triple negative breast cancer aggression through modulation of notch signaling and epithelial-to-mesenchymal transition. Experimental Cell Research: -, 2018

Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1. Molecular Medicine Reports 11(5): 3235-3542, 2016

Radiation-induced Notch signaling in breast cancer stem cells. International Journal of Radiation Oncology, Biology, Physics 87(3): 609-618, 2013

Targeting up-regulated notch signaling in the CD133+stem cells within breast cancer. 2007

MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells. Oncotarget 8(61): 103261-103273, 2017

Targeting notch signaling and estrogen receptor pathways in human breast cancer stem cells. Journal of Clinical Oncology 26(15_suppl): 22066-22066, 2016

Effects of Notch-1 down-regulation on malignant behaviors of breast cancer stem cells. Journal of Huazhong University of Science and Technology. Medical Sciences 34(2): 195-200, 2014

Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. Anticancer Research 30(10): 3853-3867, 2010

Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling. Cancer Research 76(11): 3156-3165, 2016

Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: An epigenetic regulation of miR-148a/SMAd2 signaling. Molecular Carcinogenesis 55(5): 929-940, 2016

Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. Journal of Mammary Gland Biology and Neoplasia 11(1): 41-52, 2006

p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1. Journal of Cellular Physiology 230(12): 3115-3127, 2015

Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways. Molecular Cancer 16(1): 57-57, 2017

Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations. Cancer Medicine 1(2): 105-113, 2013