+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Repeated intramuscular injections of nerve growth factor induced progressive muscle hyperalgesia, facilitated temporal summation, and expanded pain areas



Repeated intramuscular injections of nerve growth factor induced progressive muscle hyperalgesia, facilitated temporal summation, and expanded pain areas



Pain 154(11): 2344-2352



Intramuscular injection of nerve growth factor (NGF) is known to induce deep-tissue mechanical hyperalgesia. In this study it was hypothesised that daily intramuscular injections of NGF produce a progressive manifestation of soreness, mechanical hyperalgesia, and temporal summation of pain. In a double-blind placebo-controlled design, 12 healthy subjects were injected on 3 days with NGF into the tibialis anterior muscle and with isotonic saline on the contralateral side. Assessments were performed before and after the injections on days 0, 1, and 2, and repeated on days 3, 6, and 10. The self-perceived muscle soreness was assessed on a Likert scale. Computer-controlled pressure algometry was used to assess the pressure pain thresholds (PPTs). Temporal summation of pain after repeated pressure stimulations was assessed by computer-controlled pressure algometry. The pain distribution following painful pressure stimulation was also recorded. Compared with baseline and isotonic saline, the NGF injections caused (P<0.05): (1) progressively increasing soreness scores from 3 hours after the first injection until day 2, after which it remained increased; (2) decreased PPTs at days 1 to 3; (3) facilitated temporal summation of pressure pain at days 1 to 10; and (4) enlarged pressure-induced pain area after the injection on day 1 to day 6. The daily injections of NGF produced a progressive manifestation of muscle soreness, mechanical hyperalgesia, temporal summation of pressure pain, and pressure-induced pain distribution. These data illustrate that the prolonged NGF application affects peripheral and central mechanisms and may reflect process in musculoskeletal pain conditions.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055494883

Download citation: RISBibTeXText

PMID: 23867729

DOI: 10.1016/j.pain.2013.07.007


Related references

Repeated intramuscular injections of nerve growth factor induced parogressive muscle hyperalgesia, facilitated temporal summation and expanded pain areas. 2013

Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions. European Journal of Pain 13(7): 704-710, 2009

Local pain and spreading hyperalgesia induced by intramuscular injection of nerve growth factor are not reduced by local anesthesia of the muscle. Clinical Journal of Pain 27(3): 240-247, 2011

Experimental knee pain evoke spreading hyperalgesia and facilitated temporal summation of pain. Pain Medicine 14(6): 874-883, 2013

Enlarged Areas of Pain and Pressure Hypersensitivityby Spatially Distributed Intramuscular Injections ofLow-Dose Nerve Growth Factor. Journal of Pain 20(5): 566-576, 2019

Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humans. Experimental Brain Research 191(3): 371-382, 2008

Movement Evoked Pain and Mechanical Hyperalgesia after Intramuscular Injection of Nerve Growth Factor: A Model of Sustained Elbow Pain. Pain Medicine 16(11): 2180-2191, 2015

Interaction between ultraviolet B-induced cutaneous hyperalgesia and nerve growth factor-induced muscle hyperalgesia. European Journal of Pain 20(7): 1058-1069, 2016

ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections. Pain Research and Treatment 2012: 817347, 2012

The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependent. Neuroreport 8(4): 807-810, 1997

Involvement of interleukin-1 beta, nerve growth factor, and prostaglandin-E2 in the hyperalgesia induced by intraplantar injections of low doses of thymulin. Brain Behavior and Immunity 11(3): 185-200, 1997

Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats. Neuroscience 398: 252-262, 2019

Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain 106(3): 229-239, 2003

Dynamic, but not static, pain sensitivity predicts exercise-induced muscle pain: covariation of temporal sensory summation and pain intensity. Neuroscience Letters 526(1): 1-4, 2012

Young females with long-standing patellofemoral pain display impaired conditioned pain modulation, increased temporal summation of pain, and widespread hyperalgesia. Pain 159(12): 2530-2537, 2018