+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Reproductive actions of prolactin mediated through short and long receptor isoforms



Reproductive actions of prolactin mediated through short and long receptor isoforms



Molecular and Cellular Endocrinology 382(1): 400-410



Prolactin (PRL) is a polypeptide hormone with a wide range of physiological functions, and is critical for female reproduction. PRL exerts its action by binding to membrane bound receptor isoforms broadly classified as the long form and the short form receptors. Both receptor isoforms are highly expressed in the ovary as well as in the uterus. Although signaling through the long form is believed to be more predominant, it remains unclear whether activation of this isoform alone is sufficient to support reproductive functions or whether both types of receptor are required. The generation of transgenic mice selectively expressing either the short or the long form of PRL receptor has provided insight into the differential signaling mechanisms and physiological functions of these receptors. This review describes the essential finding that both long and short receptor isoforms are crucial for ovarian functions and female fertility, and highlights novel mechanisms of action for these receptors.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055509213

Download citation: RISBibTeXText

PMID: 24060636

DOI: 10.1016/j.mce.2013.09.016


Related references

Prolactin receptor heterogeneity: processing and signalling of the long and short isoforms during development. Biochemical Society Transactions 29(Pt 2): 52-56, 2001

The short of long isoforms of the dopamine D2 receptor differentially regulate prolactin synthesis and release in the lactotrophs. Society for Neuroscience Abstracts 23(1-2): 589, 1997

The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of the D2 receptor regulating prolactin release and cAMP. Society for Neuroscience Abstracts 27(2): 1766, 2001

Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons. Journal of Biological Chemistry 288(48): 34943-34955, 2013

Visualization of gene expression of short and long forms of prolactin receptor in rat reproductive tissues. Biology of Reproduction 49(3): 528-536, 1993

Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: implications for leptin's actions. Metabolism: Clinical and Experimental 49(12): 1537-1541, 2000

Subcellular distribution of the long and short isoforms of the growth hormone (GH) receptor in rat adipocytes: both isoforms participate in specific binding of GH. Endocrinology 134(1): 307-314, 1994

Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues. Reproductive Biology and Endocrinology 7: 87, 2009

Human prolactin receptor variants in breast cancer: low ratio of short forms to the long-form human prolactin receptor associated with mammary carcinoma. Cancer Research 64(16): 5677-5682, 2004

Comparison of long and short forms of the prolactin receptor on prolactin induced milk protein gene transcription. Proceedings of the National Academy of Sciences of the United States of America 88(3): 824-828, 1991

Impact of subdomain D1 of the short form S1b of the human prolactin receptor on its inhibitory action on the function of the long form of the receptor induced by prolactin. Biochimica et Biophysica Acta 1840(7): 2272-2280, 2014

Prolactin receptors in sheep ovary Regulated expression of the long but not the short prolactin receptor isoform throughout the estrous cycle. Theriogenology 59(1): 412, 2003

Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function. Biology of Reproduction 86(3): 86, 2012

Gene structure and seasonal expression of carp fish prolactin short receptor isoforms. Journal of Cellular Biochemistry 100(4): 970-980, 2007