+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Respiratory syncytial virus outbreak defined by rapid screening in a neonatal intensive care unit



Respiratory syncytial virus outbreak defined by rapid screening in a neonatal intensive care unit



Journal of Hospital Infection 75(4): 292-294



Palivizumab is currently licensed for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in infants and children with chronic lung disease, with a history of preterm birth, or with haemodynamically significant congenital heart disease, but its routine use during outbreaks in neonatal intensive care units (NICUs) is not currently recommended. Here we report an outbreak in a NICU detected during a screening trial for RSV infection using a rapid antigen test (Respi-Strip((R))). Eleven preterm infants in our NICU tested positive for RSV during January 2009. Subsequent testing of the remaining infants in the NICU revealed two additional asymptomatic cases. In addition to precautions against cross-infection, palivizumab prophylaxis was administered to the remaining 37 premature infants. Two days after treatment, RSV was detected in two additional infants who had become symptomatic. To our knowledge this is the largest RSV outbreak in a NICU to be identified at an early stage by rapid testing and effectively controlled by infection control measures and palivizumab prophylaxis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055526872

Download citation: RISBibTeXText

PMID: 20299133

DOI: 10.1016/j.jhin.2010.01.013


Related references

Pseudo-outbreak of respiratory syncytial virus infection in a neonatal intensive care unit due to cross-reactivity of surfactant and a rapid immunoassay. Infection Control and Hospital Epidemiology 30(9): 890-892, 2009

Outbreak of respiratory syncytial virus infection in a neonatal intensive care unit. Israel Journal of Medical Sciences 20(12): 1199-1201, 1984

Palivizumab use during respiratory syncytial virus outbreak in the neonatal intensive care unit. Journal of Hospital Infection 81(4): 292-293, 2012

Palivizumab prophylaxis during respiratory syncytial virus outbreak in the neonatal intensive care unit. Turkish Journal of Pediatrics 55(2): 237-238, 2013

Outbreak of respiratory syncytial virus at a neonatal intensive care unit in Mexico City. Boletin Medico del Hospital Infantil de Mexico 50(10): 709-716, 1993

Respiratory syncytial virus outbreak in a tertiary hospital Neonatal Intensive Care Unit. Anales de Pediatria 85(3): 119-127, 2016

Use of palivizumab to control an outbreak of syncytial respiratory virus in a neonatal intensive care unit. Journal of Hospital Infection 58(1): 38-41, 2004

Medical and Economic Impact of a Respiratory Syncytial Virus Outbreak in a Neonatal Intensive Care Unit. Yearbook of Neonatal and Perinatal Medicine 2007: 100-101, 2007

Medical and economic impact of a respiratory syncytial virus outbreak in a neonatal intensive care unit. Pediatric Infectious Disease Journal 24(12): 1040-1044, 2005

Containment therapy and cost of a nosocomial respiratory syncytial virus rsv outbreak in a neonatal intensive care unit. Pediatric Research 23(4 Part 2): 442A, 1988

Respiratory syncytial virus outbreak in neonatal intensive care unit Impact of infection control measures plus palivizumab use. Antimicrobial Resistance and Infection Control 1(1): 16, 2012

Respiratory syncytial virus outbreak in neonatal intensive care unit: Impact of infection control measures plus palivizumab use. Antimicrobial Resistance and Infection Control 1(1): 16-16, 2012

Use and Interpretation of a Rapid Respiratory Syncytial Virus Antigen Detection Test Among Infants Hospitalized in a Neonatal Intensive Care Unit - Wisconsin, March 2015. Mmwr. Morbidity and Mortality Weekly Report 64(31): 857, 2015

Use of palivizumab and infection control measures to control an outbreak of respiratory syncytial virus in a neonatal intensive care unit confirmed by real-time polymerase chain reaction. Journal of Hospital Infection 77(4): 338-342, 2011

Respiratory syncytial virus infection in a neonatal intensive care unit. Pediatric Research 49(4 Part 2): 401A, 2001