+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Retinal detachment and prophylaxis in type 1 Stickler syndrome



Retinal detachment and prophylaxis in type 1 Stickler syndrome



Ophthalmology 115(1): 164-168



To report the prevalence of retinal detachment (RD) and results of prophylaxis against detachment from a giant retinal tear in a large cohort of patients with type 1 Stickler syndrome. Retrospective study. Two hundred four type 1 Stickler syndrome patients. Pedigrees and individuals with type 1 Stickler syndrome were identified from the vitreous research clinic and divided into 3 groups. Group 1 consisted of patients who received no prophylaxis (control group). Group 2 consisted of patients who had bilateral 360 degrees prophylactic cryotherapy (study group). Group 3 consisted of patients referred with unilateral RD for surgical repair and who underwent prophylaxis in the fellow eye (mixed group). Retinal status after prophylaxis, with failure of prophylaxis being defined as the development of RD or retinal tears needing further retinopexy. Of 111 patients who had no prophylactic retinopexy (group 1; mean age, 49 years), 73% (81/111) suffered RD and 48% (53/111) were bilateral. Of 62 patients who had bilateral prophylactic cryotherapy (group 2; mean age, 21 years), 8% (5/62) suffered failure of prophylaxis. There were no cases of bilateral detachments. The mean follow-up period was 11.5 years. In 31 patients who had unilateral prophylactic cryotherapy to the fellow eye (group 3; mean age, 36 years), failure occurred in 10% (3/31) of cases with a mean follow-up of 15.5 years. The prevalence of failure of prophylaxis in treated patients was significantly less than prevalence of RD in untreated patients (chi2(1) = 119.2, P<0.001). Prophylactic cryotherapy substantially reduces the risk of RD in type 1 Stickler syndrome and, in this series, eliminated the risk of bilateral detachments.

(PDF emailed within 0-6 h: $19.90)

Accession: 055545031

Download citation: RISBibTeXText

PMID: 17675240

DOI: 10.1016/j.ophtha.2007.03.059


Related references

Retinal detachment in identical twins with Stickler syndrome type 1. British Journal of Ophthalmology 80(11): 976-981, 1996

Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy). American Journal of Human Genetics 53(1): 55-61, 1993

Stickler syndrome with rhegmatogenous retinal detachment. Nippon Ganka Gakkai Zasshi 114(5): 454-458, 2010

Retinal detachment in two cases of Stickler syndrome. Rinsho Ganka 59(7): 1125-1129, 2005

Stickler syndrome. Epidemiology of retinal detachment. Archivos de la Sociedad Espanola de Oftalmologia 90(6): 264-268, 2017

Prevention of retinal detachment in Wagner-Stickler syndrome. Bulletin des Societes d'Ophtalmologie de France 89(5): 657-664, 1989

Management of retinal detachment in the Wagner-Stickler syndrome. Transactions of the Ophthalmological Societies of the United Kingdom 104: 875-879, 1985

Bilateral Asymmetric Rhegmatogenous Retinal Detachment in a Patient with Stickler Syndrome. Turkish Journal of Ophthalmology 48(2): 95-98, 2018

Retinal Detachment in a Combined Case of Stickler Syndrome and X-Linked Retinoschisis. Ophthalmic Surgery, Lasers and Imaging Retina 48(1): 83-86, 2017

Wagner stickler syndrome management of retinal detachment and neovascular glaucoma. Glaucoma 10(2): 52-56, 1988

The clinical effectiveness and safety of prophylactic retinal interventions to reduce the risk of retinal detachment and subsequent vision loss in adults and children with Stickler syndrome: a systematic review. Health Technology Assessment 15(16): Iii-Xiv, 1-62, 2011

Stickler's syndrome (dystrophia vitreoretinalis hereditaria). Results of surgery for retinal detachment. Ceska a Slovenska Oftalmologie 57(3): 147-154, 2001

Prevention of retinal detachment in Stickler syndrome: the Cambridge prophylactic cryotherapy protocol. Ophthalmology 121(8): 1588-1597, 2014

Retinal detachment and infantile-onset glaucoma in Stickler syndrome associated with known and novel COL2A1 mutations. Ophthalmic Genetics 39(5): 615-618, 2018

Long-term surgical outcomes of retinal detachment in patients with Stickler syndrome. Clinical Ophthalmology 10: 1531-1534, 2016