EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor


Retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor



Proceedings of the National Academy of Sciences of the United States of America 105(36): 13638-13643



ISSN/ISBN: 0027-8424

PMID: 18757739

DOI: 10.1073/pnas.0807178105

The structural and functional properties of the visual system are disrupted in mutant animals lacking the beta2 subunit of the nicotinic acetylcholine receptor. In particular, eye-specific retinogeniculate projections do not develop normally in these mutants. It is widely thought that the developing retinas of beta2(-/-) mutants do not manifest correlated activity, leading to the notion that retinal waves play an instructional role in the formation of eye-specific retinogeniculate projections. By multielectrode array recordings, we show here that the beta2(-/-) mutants have robust retinal waves during the formation of eye-specific projections. Unlike in WT animals, however, the mutant retinal waves are propagated by gap junctions rather than cholinergic circuitry. These results indicate that lack of retinal waves cannot account for the abnormalities that have been documented in the retinogeniculate pathway of the beta2(-/-) mutants and suggest that other factors must contribute to the deficits in the visual system that have been noted in these animals.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055546103

Download citation: RISBibTeXText

Related references

Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor. Synapse 54(4): 200-206, 2004

Levels of cholinergic ligand binding in mutant mice lacking the beta-2 subunit of the neuronal nicotinic acetylcholine receptor. Society for Neuroscience Abstracts 22(1-3): 1260, 1996

Abnormal functional organization in the dorsal lateral geniculate nucleus of mice lacking the beta 2 subunit of the nicotinic acetylcholine receptor. Neuron 40(6): 1161-1172, 2003

Mice lacking specific nicotinic acetylcholine receptor subunits exhibit dramatically altered spontaneous activity patterns and reveal a limited role for retinal waves in forming ON and OFF circuits in the inner retina. Journal of Neuroscience: the Official Journal of the Society for Neuroscience 20(20): 7672-7681, 2000

Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures. Physiological Genomics 17(2): 221-229, 2004

Autonomic function in mice lacking a5 neuronal nicotinic acetylcholine receptor subunit. The Journal of Physiology 542(2): 7-54, 2002

Autonomic function in mice lacking α5 neuronal nicotinic acetylcholine receptor subunit. Journal of Physiology 542(2): 347-354, 2002

Autonomic function in mice lacking alpha5 neuronal nicotinic acetylcholine receptor subunit. Journal of Physiology 542(Pt 2): 347-354, 2002

Biochemical and anatomical subdivision of the dorsal lateral geniculate nucleus in normal mice and in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor. Vision Research 44(28): 3365-3376, 2004

Attenuated dopaminergic neurodegeneration and motor dysfunction in hemiparkinsonian mice lacking the α5 nicotinic acetylcholine receptor subunit. Neuropharmacology 138: 371-380, 2018

Postsynaptic development of the neuromuscular junction in mice lacking the gamma-subunit of muscle nicotinic acetylcholine receptor. Journal of Molecular Neuroscience: Mn 40(1-2): 21-26, 2010

Sevoflurane Anesthesia Alters Exploratory and Anxiety-like Behavior in Mice Lacking the β2 Nicotinic Acetylcholine Receptor Subunit. Anesthesiology (Philadelphia) 109(5): 790-798, 2008

Visual Response Properties in the Dorsal Lateral Geniculate Nucleus of Mice Lacking the b2 Subunit of the Nicotinic Acetylcholine Receptor. Journal of Neuroscience 24(39 S 29 2004): 59-69, 2004

Sevoflurane anesthesia alters exploratory and anxiety-like behavior in mice lacking the beta2 nicotinic acetylcholine receptor subunit. Anesthesiology 109(5): 790-798, 2008

The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology 189(3): 395-401, 2006