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Rhodium-catalyzed ring opening of benzocyclobutenols with site-selectivity complementary to thermal ring opening



Rhodium-catalyzed ring opening of benzocyclobutenols with site-selectivity complementary to thermal ring opening



Journal of the American Chemical Society 134(42): 17502-4



A rhodium catalyst induced ring opening of benzocyclobutenols with selective cleavage of the C(sp(2))-C(sp(3)) bond adjacent to the hydroxyl group. The site-selectivity markedly contrasted with that of their thermal ring-opening reaction. The rhodium-catalyzed ring opening led to the development of a new alkyne insertion reaction constructing a dihydronaphthalene framework.

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Accession: 055571273

Download citation: RISBibTeXText

PMID: 23043426

DOI: 10.1021/ja309013a


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