+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Risk factors affecting nasal colonization of methicillin-resistant Staphylococcus aureus when admitted in intensive care unit



Risk factors affecting nasal colonization of methicillin-resistant Staphylococcus aureus when admitted in intensive care unit



Chinese Medical Journal 127(10): 1804-1807



Colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a risk factor for subsequent invasive MRSA infection, particularly in patients admitted for critical care. The purpose of this study was to investigate the risk factors affecting nasal colonization of MRSA in patients admitted to intensive care units (ICU). Between August 1, 2011 and June 30, 2012, we screened for MRSA nasal colonization in 350 patients by Real-time PCR within 24 hours of admission by means of swab samples taken from the anterior nares. According to the results of PCR, the patients were divided into 2 groups: the positive group with nasal MRSA colonization and the negative group without nasal MRSA colonization. The 31 (8.86%) patients were MRSA positive. The risk factors evaluated included thirteen variables, which were analyzed by t test for continuous variables and χ(2) test for discrete variables. The variables with significance (P < 0.05) were analyzed with stepwise Logistic regression. There were differences (P < 0.05) in four variables between two groups. The duration of stay in hospital prior to ICU admission in the positive group was (35.7 ± 16.1) days, vs. (4.5 ± 3.1) days in the negative group. The average blood albumin level was (28.4 ± 2.9) g/L in the positive group, vs. (30.5 ± 4.3) g/L in the negative group. Of 31 patients in the positive group, seven had been treated with antibiotics longer than seven days vs. 34 of 319 patients in the negative group. In the positive group, four of 31 patients received treatment with more than two classes of antibiotics prior to admission in ICU, contrasted to 13 of 319 patients in the negative group. Furthermore, stepwise Logistic regression analysis for these four variables indicates that the duration of stay in hospital prior to ICU admission may be an independent risk factor. MRSA colonization in ICU admission may be related to many factors. The duration of stay in hospital prior to ICU admission is an independent risk factor.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055578926

Download citation: RISBibTeXText

PMID: 24824235


Related references

Risk factors for and impact of methicillin-resistant Staphylococcus aureus nasal colonization in patients in a medical intensive care unit. American Journal of Infection Control 41(11): 1100-1101, 2014

Methicillin-resistant Staphylococcus aureus nasal colonization in a level III neonatal intensive care unit: Incidence and risk factors. American Journal of Infection Control 43(5): 476-481, 2016

Methicillin-resistant Staphylococcus aureus nasal colonization is a poor predictor of intensive care unit-acquired methicillin-resistant Staphylococcus aureus infections requiring antibiotic treatment. Critical Care Medicine 38(10): 1991-1995, 2010

Nasal colonization with methicillin-resistant Staphylococcus aureus on admission to the surgical intensive care unit increases the risk of infection. Anesthesia and Analgesia 78(4): 644-650, 1994

Methicillin-resistant Staphylococcus aureus colonization in a pediatric intensive care unit: risk factors. American Journal of Infection Control 40(2): 118-122, 2013

Risk Factors for Persistent Methicillin-Resistant Staphylococcus aureus Colonization in Children with Multiple Intensive Care Unit Admissions. 2013

Risk factors for persistent methicillin-resistant Staphylococcus aureus colonization in children with multiple intensive care unit admissions. Infection Control and Hospital Epidemiology 34(7): 748-750, 2014

Risk factors for methicillin-resistant Staphylococcus aureus colonization in the neonatal intensive care unit: A systematic review and meta-analysis. American Journal of Infection Control 45(12): 1388-1393, 2018

Incidence of and risk factors for community-associated methicillin-resistant Staphylococcus aureus acquired infection or colonization in intensive-care-unit patients. Journal of Clinical Microbiology 48(12): 4439-4444, 2011

Prevalence of and risk factors for methicillin-resistant Staphylococcus aureus colonization and infection among infants at a level III neonatal intensive care unit. American Journal of Infection Control 39(1): 35-41, 2011

Dynamics of the nasal colonization by methicillin resistant Staphylococcus aureus in patients hospitalized in an intensive care unit. Pathologie-Biologie 43(4): 329-335, 1995

Methicillin-resistant Staphylococcus aureus nasal colonization and infection in an intensive care unit of a university hospital in China. Journal of International Medical Research 46(9): 3698-3708, 2018

Risk Factors of Methicillin-Resistant Staphylococcus aureus Infection and Correlation With Nasal Colonization Based on Molecular Genotyping in Medical Intensive Care Units: A Prospective Observational Study. Medicine 94(28): E1100, 2015

"Colonization pressure" and risk of acquisition of methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infection Control and Hospital Epidemiology 21(11): 718-723, 2000

Case-case-control study of risk factors for nasopharyngeal colonization with methicillin-resistant Staphylococcus aureus in a medical-surgical intensive care unit. Brazilian Journal of Infectious Diseases 13(6): 398-402, 2010