+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Risk factors and incidence of de novo malignancy in liver transplant recipients: a systematic review



Risk factors and incidence of de novo malignancy in liver transplant recipients: a systematic review



Liver International 30(9): 1247-1258



Orthotopic liver transplant (OLT) is an established life saving procedure for both acute and chronic liver failure, but incidences and risk factors for development of these malignancies are yet to be established. To determine the incidences and risk factors associated with de novo malignancy after OLT. We performed a systematic review of relevant epidemiological studies available on MEDLINE, which provided information on the incidences and risk factors for the development malignancies in adult OLT recipients published from 1983 to 2009. All data was compiled from retrospective studies. Independent risk factors for the development of de novo malignancy in adult OLT recipients were identified to be statistically significant including immunosuppression, hepatitis C virus infection, smoking, alcoholic cirrhosis and sun exposure. OLT recipients with smoking and alcohol history are of particular risk for head and neck and lung cancers. Primary sclerosing cholangitis and inflammatory bowel disease were found to be independent risk factors for colon cancer. Adult OLT recipients are at increased risk for the development of post-transplant malignancies and obviates the need for surveillance protocols that are safe and cost-effective. OLT recipients should be advised on taking proper precautions in the sun, smoking cessation, and eliminating alcohol consumption. Given the emergence of alcoholic cirrhosis as a leading indication for liver transplantation, the early detection of lung and head and neck cancers is of particular importance.

(PDF emailed within 0-6 h: $19.90)

Accession: 055579130

Download citation: RISBibTeXText

PMID: 20602682

DOI: 10.1111/j.1478-3231.2010.02303.x


Related references

The incidence and risk factors of de novo skin cancer in the liver transplant recipients. International Journal of Organ Transplantation Medicine 3(4): 157-163, 2012

Incidence, risk factors and outcome of de novo tumors in liver transplant recipients focusing on alcoholic cirrhosis. World Journal of Hepatology 7(7): 942-953, 2015

Comparison of the incidence of de novo malignancy in liver or kidney transplant recipients: analysis of 2673 consecutive cases in a single center. Transplantation Proceedings 45(8): 3019-3023, 2014

Everolimus in de novo liver transplant recipients: a systematic review. Hepatobiliary & Pancreatic Diseases International 14(5): 461-469, 2015

Everolimus in de novo liver transplant recipients: a systematic review. Hepatobiliary & Pancreatic Diseases International 14(5): 461-469, 2016

Immunosuppression, Race, and Donor-Related Risk Factors Affect De novo Cancer Incidence Across Solid Organ Transplant Recipients. Mayo Clinic Proceedings, 2018

Survival after the diagnosis of de novo malignancy in liver transplant recipients. International Journal of Cancer, 2018

Incidence and risk factors of EBV related post transplant lymphoproliferative diseases in paediatric liver transplant recipients treated with tacrolimus. Hepatology 26(4 PART 2): 343A, 1997

Risk indicators of de novo malignancy in renal transplant recipients. Transplantation Proceedings 9(1): 1129-1132, 1977

Incidence and Risk Factors of Intracranial Hemorrhage in Liver Transplant Recipients. Transplantation, 2017

Distribution of lymphocyte subtypes in liver transplant recipients with viral reinfection or de novo malignancy. Transplantation Proceedings 30(5): 1846-1847, 1998

Wound infections in liver transplant recipients Incidence, risk factors, and impact on outcomes The NIDDK liver transplantation database. Hepatology 18(4 PART 2): 324A, 1993

Bone disease in liver transplant recipients: incidence, timing, and risk factors. Transplantation Proceedings 23(1 Pt 2): 1462-1465, 1991

Hypogammaglobulinemia in liver transplant recipients: incidence, timing, risk factors, and outcomes. Transplantation 81(5): 697-703, 2006

Risk of cytomegalovirus disease in high-risk liver transplant recipients on valganciclovir prophylaxis: a systematic review and meta-analysis. Liver Transplantation 18(12): 1440-1447, 2013