+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Risk factors and mechanisms of non-alcoholic steatohepatitis



Risk factors and mechanisms of non-alcoholic steatohepatitis



Pathophysiology 15(2): 109-114



The worldwide proportion of overweight and obese individuals has increased yearly for more than a decade. Along with rates of obesity, the incidence of co-morbid conditions such as type 2 diabetes, cardiovascular disease and liver disease has also increased. The form of liver disease associated with obesity is termed non-alcoholic steatohepatitis (NASH) due to the histological similarities to livers of chronic alcoholics. NASH has been observed in adult as well as pediatric populations; however, the etiology of this disease is still unknown. This review outlines some of the risk factors commonly associated with NASH and describes molecular mechanisms proposed to underlie disease pathogenesis.

(PDF emailed within 0-6 h: $19.90)

Accession: 055579182

Download citation: RISBibTeXText

PMID: 18667295

DOI: 10.1016/j.pathophys.2008.04.003


Related references

Prevalence and risk factors for biopsy-proven non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in a prospective cohort of adult patients with gallstones. Liver International 35(8): 1983-1991, 2016

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. Journal of Hepatology 51(2): 371-379, 2009

Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients. International Journal of Molecular Sciences 16(10): 25552-9, 2016

Risk factors of fatty liver and non-alcoholic steatohepatitis among Chilean Mapuche Indians. Gastroenterology 122(4 Suppl 1): A-304, April, 2002

The natural history and risk factors for progression of non-alcoholic fatty liver disease and steatohepatitis. European Review for Medical and Pharmacological Sciences 9(5): 273-277, 2005

Incidence and risk factors for non-alcoholic steatohepatitis in females treated with tamoxifen for breast cancer. Arab Journal of Gastroenterology 12(1): 34-36, 2011

Prevalence of Non-alcoholic Fatty Liver Disease and Steatohepatitis Risk Factors in Patients Undergoing Bariatric Surgery. Obesity Surgery 25(12): 2335-2343, 2016

Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial. Bmj 330(7497): 932-932, 2005

Comparison of clinical, biochemical and histological features of alcoholic steatohepatitis and non-alcoholic steatohepatitis in Asian Indian patients. Indian Journal of Pathology & Microbiology 53(3): 408-413, 2010

Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis. Journal of Gastroenterology and Hepatology 27 Suppl 2(): 52-57, 2012

Non-alcoholic steatohepatitis and iron: Increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. Journal of Hepatology 31(3): 421-429, Sept, 1999

Mechanisms of non-alcoholic steatohepatitis. Alcohol 34(1): 67-79, 2005

Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis. Diabetes & Metabolism Journal 40(1): 1-11, 2016

Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis. Current Hepatology Reports 13(2): 119-129, 2014