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Risk factors and mechanisms of non-alcoholic steatohepatitis

Risk factors and mechanisms of non-alcoholic steatohepatitis

Pathophysiology 15(2): 109-114

The worldwide proportion of overweight and obese individuals has increased yearly for more than a decade. Along with rates of obesity, the incidence of co-morbid conditions such as type 2 diabetes, cardiovascular disease and liver disease has also increased. The form of liver disease associated with obesity is termed non-alcoholic steatohepatitis (NASH) due to the histological similarities to livers of chronic alcoholics. NASH has been observed in adult as well as pediatric populations; however, the etiology of this disease is still unknown. This review outlines some of the risk factors commonly associated with NASH and describes molecular mechanisms proposed to underlie disease pathogenesis.

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Accession: 055579182

Download citation: RISBibTeXText

PMID: 18667295

DOI: 10.1016/j.pathophys.2008.04.003

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