+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Risk factors associated with progression in exfoliative glaucoma patients



Risk factors associated with progression in exfoliative glaucoma patients



Ophthalmic Research 47(4): 208-213



To evaluate exfoliative glaucoma (XFG) patients over 5 years, determining risk factors associated with progression or non-progression of glaucoma. A retrospective, observational study. Patients were chosen from consecutive charts and data collected from each available visit included in the follow-up period. Data were abstracted for non-progressed XFG patients for 5 years and for progressed patients until glaucoma worsened. Progression was determined from patient records and by disc photographs. There were 71 (53%) progressed and 63 (47%) non-progressed XFG patients.Baseline parameters demonstrated worse visual field damage (p=0.014) and more prescribed medicines (p=0.03) in progressed patients. The mean intraocular pressure (IOP) for progressed patients was 18.7±4.3 and 17.3±3.4 mm Hg for non-progressed patients (p=0.047). The mean IOP that best separated the groups was 17 mm Hg with 60% staying non-progressed at or below this level and 30% above this level. At the last visit, progressed patients had more medicines prescribed (1.7) than non-progressed patients (1.3, p=0.005). A multivariate regression analysis showed higher mean, peak and variance of IOP, number of glaucoma medications at the final visit and presence of a disc hemorrhage (n=5) as independent risk factors for progression (p≤0.05). IOP reduction in XFG may be essential in reducing disease progression. The presence of disc hemorrhage in XFG may suggest an increased probability of progression despite treatment to within the normal IOP range.

(PDF emailed within 0-6 h: $19.90)

Accession: 055579822

Download citation: RISBibTeXText

PMID: 22178774

DOI: 10.1159/000332081


Related references

Risk factors and long term progression in open angle glaucoma patients. Romanian Journal of Ophthalmology 60(3): 174-180, 2016

Mode of progression of visual field defects and risk factors in glaucoma patients. Nippon Ganka Gakkai Zasshi 101(7): 593-597, 1997

Risk factors for progression of visual field defects in medically treated patients with glaucoma. Canadian Journal of Ophthalmology. Journal Canadien d'Ophtalmologie 17(6): 245-248, 1982

Risk factors for visual field progression of normal-tension glaucoma in patients with myopia. Canadian Journal of Ophthalmology. Journal Canadien d'Ophtalmologie 52(1): 107-113, 2017

Canadian Glaucoma Study: 2. risk factors for the progression of open-angle glaucoma. Archives of Ophthalmology 126(8): 1030-1036, 2008

Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. Journal of Glaucoma 25(4): E372-E376, 2016

Comparison of Glaucoma Progression Between Unilateral and Bilateral Disc Hemorrhage Eyes and Associated Risk Factors for Progression. Journal of Glaucoma 27(6): E121, 2018

Comparison of Glaucoma Progression Between Unilateral and Bilateral Disc Hemorrhage Eyes and Associated Risk Factors for Progression. Journal of Glaucoma 26(9): 774-779, 2017

Risk factors for predicting visual field progression in Chinese patients with primary open-angle glaucoma: A retrospective study. Journal of the Chinese Medical Association 78(7): 418-423, 2017

Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk. Clinical and Experimental Ophthalmology 43(1): 26-30, 2015

Glaucoma and risk factors. Comparative study of cardiovascular risk factors in primary open-angle glaucoma, normal-pressure glaucoma and simple ocular hypertension. Revue Medicale de la Suisse Romande 116(1): 51-58, 1996

Comparison of survival of exfoliative glaucoma patients and primary open-angle glaucoma patients: impact of acetazolamide use. Acta Ophthalmologica Scandinavica 82(4): 397-400, 2004

Intraocular pressure and progression in exfoliative eyes with ocular hypertension or glaucoma. Acta Ophthalmologica Scandinavica 78(6): 699-702, 2000

Risk factors that predict glaucoma progression. ARVO Annual Meeting Abstract Search & Program Planner : Abstract No 2045, 2003

Risk factors for glaucoma onset and progression. Survey of Ophthalmology 53 Suppl1: S3-10, 2008