+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Risk factors associated with the postoperative recurrence of intraductal papillary mucinous neoplasms of the pancreas



Risk factors associated with the postoperative recurrence of intraductal papillary mucinous neoplasms of the pancreas



Pancreas 40(1): 46-51



The risk factors correlated with the post-operative recurrence of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are not well established. The aim was to determine the risk factors of recurrence. We reviewed retrospectively the differences of clinicopathologic features between the recurrence and nonrecurrence groups of patients with IPMN who underwent surgical resection and analyzed the recurrence-related factors. A total of 103 patients were confirmed to have IPMNs. The mean postoperative follow-up was 3.2 years, and the recurrence rate was 12.6%. Recurrent cases (n=13) had the following pathologic grades: adenoma, 1; and invasive carcinoma, 12. The mean postoperative survival was 17.0 months in the recurrence group and 41.4 months in the nonrecurrence group (P<0.001). The independent risk factors of recurrence were invasive carcinoma (P=0.017, hazard ratio=71.79; 95% confidence interval (CI)=2.13-2417.05), elevated carbohydrate antigen 19-9 (P=0.007, hazard ratio=37.97, 95% CI=2.66-542.32), and main location in the pancreatic head (P=0.038, hazard ratio=0.16, 95% CI=0.03-0.90). The risk factors associated with recurrence of IPMNs were invasive pathology, elevated carbohydrate antigen 19-9, and main location in the pancreatic head. A more careful follow-up is needed for such patients.

(PDF emailed within 0-6 h: $19.90)

Accession: 055579915

Download citation: RISBibTeXText

PMID: 21160369

DOI: 10.1097/MPA.0b013e3181f66b74


Related references

Risk factors for postoperative recurrence of intraductal papillary mucinous neoplasms of the pancreas based on a long-term follow-up study: proposals for follow-up strategies. Journal of Hepato-Biliary-Pancreatic Sciences 22(10): 757-765, 2016

Noninvasive intraductal papillary mucinous neoplasms and mucinous cystic neoplasms: recurrence rates and postoperative imaging follow-up. Surgery 157(3): 473-483, 2015

Cyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: a critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms. Journal of the American College of Surgeons 220(2): 243-253, 2015

Risk factors of malignancy in intraductal papillary mucinous neoplasms of the pancreas. Pancreatology 15(3): S117-S118, 2015

Expression of trefoil factors in mucinous cystic neoplasms and intraductal papillary mucinous neoplasms of the pancreas. Modern Pathology 16(1): 271A, January, 2003

Risk factors for malignancy in branched-type intraductal papillary mucinous neoplasms of the pancreas during the follow-up period. World Journal of Surgery 39(1): 244-250, 2015

Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms. American Journal of Surgical Pathology 32(2): 243-255, 2008

A false postoperative recurrence of intraductal and papillary mucinous neoplasm of the pancreas. Journal of Visceral Surgery: -, 2018

Recurrence patterns of intraductal papillary mucinous neoplasms of the pancreas on enhanced computed tomography. Journal of Computer Assisted Tomography 33(6): 838-843, 2010

Treatment strategy for main duct intraductal papillary mucinous neoplasms of the pancreas based on the assessment of recurrence in the remnant pancreas after resection: a retrospective review. Annals of Surgery 259(2): 360-368, 2014

Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas. Virchows Archiv 469(5): 523-532, 2016

"Simple Mucinous Cyst" of the Pancreas: A Clinicopathologic Analysis of 39 Examples of a Diagnostically Challenging Entity Distinct From Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms. American Journal of Surgical Pathology 41(1): 121-127, 2016

Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival. Annals of Surgical Oncology 13(4): 582-594, 2006

Pancreatic intraepithelial neoplasia in association with intraductal papillary mucinous neoplasms of the pancreas: implications for disease progression and recurrence. American Journal of Surgical Pathology 28(9): 1184-1192, 2004

A comparison between intraductal papillary neoplasms of the biliary tract (BT-IPMNs) and intraductal papillary mucinous neoplasms of the pancreas (P-IPMNs) reveals distinct clinical manifestations and outcomes. European Journal of Surgical Oncology 39(6): 554-558, 2013