+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Risk factors associated with the relapse of uveitis in patients with juvenile idiopathic arthritis: a preliminary report



Risk factors associated with the relapse of uveitis in patients with juvenile idiopathic arthritis: a preliminary report



Journal of Aapos 17(5): 460-464



To identify risk factors associated with relapse of uveitis in patients with recurrent uveitis associated with juvenile idiopathic arthritis (JIA) after treatment with immunomodulatory therapy (IMT) and durable remission of 1 year. The medical records of 30 patients with JIA-associated uveitis who were successfully treated with IMT to a state of corticosteroid-free remission and subsequently remained in remission after discontinuation of IMT for a period of at least 1 year were retrospectively reviewed. In subsequent follow-up, some patients had relapse of uveitis, whereas others continued to be in remission. Remission was defined as <1 + cells in the anterior chamber and <1 + vitreous haze grading; relapse was defined as ≥ 1 + cell in the anterior chamber or ≥ 1 + vitreous haze grading. A total of 30 patients were included. Of these, 17 (56.7%) patients remained in uveitic remission, whereas 13 (43.3%) relapsed. The patients in remission received IMT earlier in the course of disease compared with patients who relapsed (median, 12 months vs 72 months; P = 0.002 [Mann-Whitney test]). Patients in remission had received treatment with IMT at a younger age compared with the relapse group (median age, 7 years vs 13 years; P = 0.02 [Mann-Whitney test]). None of the other factors studied revealed a statistically significant association. Patients with JIA-associated uveitis who were treated with IMT earlier in the course of disease and at a younger age were associated with a lower rate of relapse of uveitis after durable remission and 1 year of quiescence, compared with similar patients who relapsed.

(PDF emailed within 0-6 h: $19.90)

Accession: 055579924

Download citation: RISBibTeXText

PMID: 24160963

DOI: 10.1016/j.jaapos.2013.06.004


Related references

Predictive factors and biomarkers for the 2-year outcome of uveitis in juvenile idiopathic arthritis: data from the Inception Cohort of Newly diagnosed patients with Juvenile Idiopathic Arthritis (ICON-JIA) study. Rheumatology 2018, 2018

An evaluation of baseline risk factors predicting severity in juvenile idiopathic arthritis associated uveitis and other chronic anterior uveitis in early childhood. British Journal of Ophthalmology 86(1): 51-56, 2002

Risk factors for ocular complications and poor visual acuity at presentation among patients with uveitis associated with juvenile idiopathic arthritis. American Journal of Ophthalmology 143(4): 647-655, 2007

Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. Ophthalmology 120(1): 186-192, 2013

Risk factors and biomarkers for the occurrence of uveitis in JIA: Data from the Inception Cohort of Newly diagnosed patients with Juvenile Idiopathic Arthritis (ICON-JIA) study. Arthritis & Rheumatology: -, 2018

Risk factors and longterm outcome of juvenile idiopathic arthritis-associated uveitis in Switzerland. Journal of Rheumatology 35(4): 703-706, 2008

Prospective Determination of the Incidence and Risk Factors of New-Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort. Arthritis Care & Research: -, 2018

Risk factors for the development of cataract requiring surgery in uveitis associated with juvenile idiopathic arthritis. American Journal of Ophthalmology 144(4): 574-579, 2007

Risk factors for development of uveitis differ between girls and boys with juvenile idiopathic arthritis. Arthritis and Rheumatism 62(6): 1824-1828, 2010

Profiling risk factors for chronic uveitis in juvenile idiopathic arthritis: a new model for EHR-based research. Pediatric Rheumatology Online Journal 11(1): 45-45, 2013

Research progress in the risk factors of juvenile idiopathic arthritis-associated uveitis and its severe visual outcome. Zhonghua Er Ke Za Zhi 56(10): 786-789, 2018

Female sex and oligoarthritis category are not risk factors for uveitis in Italian children with juvenile idiopathic arthritis. Journal of Rheumatology 41(7): 1416-1425, 2015

Occurrence of and Risk Factors for Ocular Hypertension and Secondary Glaucoma in Juvenile Idiopathic Arthritis-associated Uveitis. Ocular Immunology and Inflammation 25(4): 503-512, 2016

Review for disease of the year: epidemiology of juvenile idiopathic arthritis and its associated uveitis: the probable risk factors. Ocular Immunology and Inflammation 21(3): 180-191, 2014

Relapse of Juvenile Idiopathic Arthritis-Associated Uveitis after Discontinuation of Immunomodulatory Therapy. Ocular Immunology and Inflammation 2018: 1-7, 2018