+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Risk factors at the low end of the psychosis continuum: much the same as at the upper end?



Risk factors at the low end of the psychosis continuum: much the same as at the upper end?



Psychiatry Research 189(1): 77-81



We investigated risk factors for subclinical symptoms of psychosis, and focused on two psychosis dimensions previously identified in the Zurich Study, namely "schizophrenia nuclear symptoms" and "schizotypal signs". We examined the data from 9814 Swiss conscripts from 2003. The psychosis symptom dimensions were derived from the Symptom-Checklist-90-R (SCL-90-R), and were regressed on a broad range of known risk factors for psychosis. Risk factors typically assigned to schizophrenia and other psychotic disorders - cannabis use, childhood adversity, reading and writing difficulties, attention deficit hyperactivity disorder (ADHD), psychiatric disorders and addiction in parents and the extended family - are relevant also at subclinical levels. Our analyses suggested that specific risk factors may be assigned to distinct psychosis dimensions, as previously determined in an analysis from the Zurich Study. If there are different pathways to psychosis characterized by specific symptom dimensions and risk factors, they mostly co-exist and interact at different symptom load levels.

(PDF emailed within 0-6 h: $19.90)

Accession: 055579961

Download citation: RISBibTeXText

PMID: 21439652

DOI: 10.1016/j.psychres.2011.02.019


Related references

Testing the psychosis continuum: differential impact of genetic and nongenetic risk factors and comorbid psychopathology across the entire spectrum of psychosis. Schizophrenia Bulletin 38(5): 992-1002, 2013

Polygenic risk score and the psychosis continuum model. Acta Psychiatrica Scandinavica 130(4): 311-317, 2015

Risk factors of schizophrenia development in patients with amphetamines dependence and psychosis (amphetamine-induced psychosis and schizophrenia), and without psychosis. Psychiatria Polska 46(4): 571-584, 2013

Stress and protective factors in individuals at ultra-high risk for psychosis, first episode psychosis and healthy controls. Schizophrenia Research 129(1): 29-35, 2011

Systematic reviews of categorical versus continuum models in psychosis: evidence for discontinuous subpopulations underlying a psychometric continuum. Implications for DSM-V, DSM-VI, and DSM-VII. Annual Review of Clinical Psychology 6: 391-419, 2010

Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactive psychosis of early onset: case-control study. Bmj 318(7181): 421-426, 1999

The Psychosis Continuum: Testing a Bifactor Model of Psychosis in a General Population Sample. Schizophrenia Bulletin (): -, 2016

Childhood abuse in the etiological continuum underlying psychosis from first-episode psychosis to psychotic experiences. European Psychiatry 30(1): 38-42, 2016

Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance. Breast Cancer Research 14(6): R144-R144, 2015

A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychological Medicine 39(2): 179-195, 2008

Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample. Schizophrenia Research 169(1-3): 340-345, 2016

Self-reported psychosis-like symptoms and the continuum of psychosis. Social Psychiatry and Psychiatric Epidemiology 34(9): 459-463, 1999

Prenatal and perinatal and perinatal risk factors for early onset schizophrenia, affective psychosis, and reactive psychosis. Bmj 318(7181): 426-426, 1999

Metacognitive beliefs across the continuum of psychosis: comparisons between patients with psychotic disorders, patients at ultra-high risk and non-patients. Behaviour Research and Therapy 45(9): 2241-2246, 2007

Risk factors for transition to first episode psychosis among individuals with 'at-risk mental states'. Schizophrenia Research 71(2-3): 227-237, 2004