+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Risk factors for hospital-acquired pneumonia caused by carbapenem-resistant Gram-negative bacteria in critically ill patients: a multicenter study in Korea



Risk factors for hospital-acquired pneumonia caused by carbapenem-resistant Gram-negative bacteria in critically ill patients: a multicenter study in Korea



Diagnostic Microbiology and Infectious Disease 78(4): 457-461



We performed a case-control study to identify risk factors of carbapenem-resistant Gram-negative bacteria (CRGNB) as an increasing cause of hospital-acquired pneumonia (HAP). The study included critically ill adult patients with HAP whose microbial etiology was identified at eight tertiary centers in Korea between June 2008 and December 2009. Eighty two patients with 86 isolates of CRGNB (62 Acinetobacter baumannii, 14 Pseudomonas aeruginosa, and 10 Stenotrophomonas maltophilia) were included in the case group, and 122 patients with carbapenem-susceptible Gram-negative bacteria were included in the control group. Diabetes mellitus (adjusted odds ratio [aOR] 2.82, 95% confidence interval [95% CI] 1.25-6.38), radiologic score ≥5 (aOR 4.56, 95% CI 2.36-8.81), prior fluoroquinolone (aOR 2.39. 95% CI = 1.07-5.35), or carbapenem usage (aOR 2.82, 95% CI 1.75-17.83) were found to be independent risk factors. Fluoroquinolone and carbapenem should be cautiously used to avoid HAP caused by CRGNB.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055581534

Download citation: RISBibTeXText

PMID: 24462178

DOI: 10.1016/j.diagmicrobio.2013.08.011


Related references

Novel pharmacotherapy for the treatment of hospital-acquired and ventilator-associated pneumonia caused by resistant gram-negative bacteria. Expert Opinion on PharmacoTherapy 19(4): 397-408, 2018

Factors influencing mortality in hospital-acquired pneumonia caused by Gram-negative bacteria in China. Journal of Infection and Public Health 2019, 2019

Tigecycline Therapy for Nosocomial Pneumonia due to Carbapenem-Resistant Gram-Negative Bacteria in Critically Ill Patients Who Received Inappropriate Initial Antibiotic Treatment: A Retrospective Case Study. Biomed Research International 2016: 8395268, 2017

Carbapenem-resistant Gram-negative bloodstream infections in critically ill children: outcome and risk factors in a tertiary teaching hospital in South America. Journal of Hospital Infection 2018, 2018

Risk factors for infection/colonization caused by resistant Gram negative bacilli in critically ill patients (an observational study of 1633 critically ill patients). Preventive Medicine 57(Suppl.): S70-S73, 2014

Bloodstream infections in children caused by carbapenem-resistant versus carbapenem-susceptible gram-negative microorganisms: Risk factors and outcome. Diagnostic Microbiology and Infectious Disease 87(4): 359-364, 2017

Epidemiology, associated factors and outcomes of ICU-acquired infections caused by Gram-negative bacteria in critically ill patients: an observational, retrospective study. Bmc Anesthesiology 15: 125, 2016

Risk Factors for Gastrointestinal Colonization and Acquisition of Carbapenem-Resistant Gram-Negative Bacteria among Patients in Intensive Care Units in Thailand. Antimicrobial Agents and ChemoTherapy 62(8), 2018

Hospital-acquired gram-negative pneumonia in critically ill, injured patients. American Journal of Surgery 165(2a Suppl): 34s-42s, 1993

Hospital-acquired pneumonia: Risk factors for antimicrobial-resistant causative pathogens in critically III patients. Chest 123(6): 2034-2042, 2003

Risk factors for infection with multidrug-resistant bacteria in non-ventilated patients with hospital-acquired pneumonia. Jornal Brasileiro de Pneumologia 39(3): 339-348, 2014

Increased Costs Associated with Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Bacteria Are Due Primarily to Patients with Hospital-Acquired Infections. Antimicrobial Agents and ChemoTherapy 61(3), 2016

Multiple antibiotic resistance as a risk factor for mortality and prolonged hospital stay: A cohort study among neonatal intensive care patients with hospital-acquired infections caused by gram-negative bacteria in Vietnam. Plos One 14(5): E0215666, 2019

Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients. World Journal of Critical Care Medicine 5(2): 111-120, 2016

Clinical outcomes and risk factors of community-acquired pneumonia caused by gram-negative bacilli. European Journal of Clinical Microbiology and Infectious Diseases 27(8): 657-661, 2008