+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Risk factors for intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma: a meta-analysis



Risk factors for intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma: a meta-analysis



Urologic Oncology 32(7): 989-1002



After radical nephroureterectomy (RNU), approximately 22% to 47% of patients with upper tract urothelial carcinoma (UTUC) develop a subsequent intravesical recurrence (IVR). Considering this high incidence of occurrence, several risk factors were reported as predictive of IVR after RNU. Until recently, most of the risk factors were still under debate. The aim of study was to conduct a meta-analysis based on the recent literature to explore the risk factors for IVR after RNU for UTUC. An electronic search of the Medline, Embase, Cochrane Library, CancerLit, and ClinicalTrials.gov databases was performed to identify relevant studies published before May 2013. The studies were included if they reported risk factors related to bladder or IVR after RNU for UTUC. Overall, 40 studies, with 12,010 patients, were included in our meta-analysis. Our study indicated that a statistically significant difference in IVR after RNU was found in the male vs. female patients (odds ratio [OR] = 0.72, 95% CI: 0.59-0.85), ureteral vs. renal pelvis (OR = 1.18, 95% CI: 1.00-1.36), T2-4 vs. Tis, Ta, and T1 (OR = 0.53, 95% CI: 0.40-0.66), larger vs. smaller tumor size (OR = 1.02, 95% CI: 1.01-1.03), and previous/synchronous bladder cancer vs. the absence of bladder cancer (OR = 1.59, 95% CI: 1.26-1.9). No significant differences in IVR after RNU were found in the younger vs. older age groups, multifocal tumors vs. single tumor, G3 vs. G1 and G2, high vs. low grade, N0 vs. N+, concomitant carcinoma in situ vs. the absence of carcinoma in situ, positive vs. negative lymphovascular invasion, open vs. laparoscopic nephroureterectomy, and endoscopic vs. transvesical technique. Our study showed that female patient; ureteral tumor; larger tumor; Tis, Ta, and T1; and the history of bladder cancer were significant risk factors related to IVR after RNU.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055581783

Download citation: RISBibTeXText

PMID: 25082191

DOI: 10.1016/j.urolonc.2014.01.022


Related references

Pd35-08 Risk Factors For Intravesical Recurrence After Radical Nephroureterectomy For Upper Tract Urothelial Carcinoma: A Meta-Analysis. The Journal of Urology 191(4): e893-e894, 2014

A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma. European Urology 67(6): 1122-1133, 2016

A systematic review and meta-analysis of clinicopathologic factors linked with intravesical recurrence after radical nephroureterectomy to treat upper tract urothelial carcinoma. European Urology Suppl.s 14(2): e332-e332a, 2015

The effect of intravesical chemotherapy in the prevention of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: a meta-analysis. Journal of ChemoTherapy 27(4): 195-200, 2016

Diagnostic Ureteroscopy Prior to Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma Increased the Risk of Intravesical Recurrence. Urologia Internationalis 100(1): 92-99, 2017

Predictors for Intravesical Recurrence Following Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A National Multicenter Analysis. Clinical Genitourinary Cancer 15(6): E1055-E1061, 2017

Risk factors for intravesical recurrence after nephroureterectomy in patients with upper urinary tract urothelial carcinoma. International Urology and Nephrology 49(3): 425-430, 2017

Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma. Surgical Oncology 26(1): 73-79, 2017

Detection of Fgfr3 mutations from urine sediment Dna to predict the risk of intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma. European Urology Suppl.s 14(2): e1056-e1056a, 2015

Impact of diagnostic ureteroscopy on intravesical recurrence in patients undergoing radical nephroureterectomy for upper tract urothelial cancer: a systematic review and meta-analysis. Bju International 120(3): 313-319, 2017

Pattern and risk factors of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: a large Chinese center experience. Journal of the Formosan Medical Association 113(11): 820-827, 2015

Endoglin expression in upper urinary tract urothelial carcinoma is associated with intravesical recurrence after radical nephroureterectomy. International Journal of Urology 22(5): 463-467, 2016

Diagnostic Ureteroscopy for Upper Tract Urothelial Carcinoma is Independently Associated with Intravesical Recurrence after Radical Nephroureterectomy. International Braz J Urol 42(6): 1129-1135, 2016

Diagnostic Ureterorenoscopy Is Associated with Increased Intravesical Recurrence following Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma. Plos One 10(11): E0139976, 2016

Clinical implications of intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma. International Journal of Urology 23(5): 378-384, 2018