+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study



Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study



Environmental Health Perspectives 120(5): 708-714



Few cohort studies have evaluated the risk of mortality associated with long-term exposure to fine particulate matter [≤ 2.5 μm in aerodynamic diameter (PM(2.5))]. This is the first national-level cohort study to investigate these risks in Canada. We investigated the association between long-term exposure to ambient PM(2.5) and cardiovascular mortality in nonimmigrant Canadian adults. We assigned estimates of exposure to ambient PM(2.5) derived from satellite observations to a cohort of 2.1 million Canadian adults who in 1991 were among the 20% of the population mandated to provide detailed census data. We identified deaths occurring between 1991 and 2001 through record linkage. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for available individual-level and contextual covariates using both standard Cox proportional survival models and nested, spatial random-effects survival models. Using standard Cox models, we calculated HRs of 1.15 (95% CI: 1.13, 1.16) from nonaccidental causes and 1.31 (95% CI: 1.27, 1.35) from ischemic heart disease for each 10-μg/m(3) increase in concentrations of PM(2.5). Using spatial random-effects models controlling for the same variables, we calculated HRs of 1.10 (95% CI: 1.05, 1.15) and 1.30 (95% CI: 1.18, 1.43), respectively. We found similar associations between nonaccidental mortality and PM2.5 based on satellite-derived estimates and ground-based measurements in a subanalysis of subjects in 11 cities. In this large national cohort of nonimmigrant Canadians, mortality was associated with long-term exposure to PM(2.5). Associations were observed with exposures to PM(2.5) at concentrations that were predominantly lower (mean, 8.7 μg/m(3); interquartile range, 6.2 μg/m(3)) than those reported previously.

(PDF emailed within 0-6 h: $19.90)

Accession: 055586729

Download citation: RISBibTeXText

PMID: 22313724

DOI: 10.1289/ehp.1104049


Related references

Long-term exposure to fine particulate matter: association with nonaccidental and cardiovascular mortality in the agricultural health study cohort. Environmental Health Perspectives 122(6): 609-615, 2015

Long-term Fine Particulate Matter Exposure and Nonaccidental and Cause-specific Mortality in a Large National Cohort of Chinese Men. Environmental Health Perspectives 125(11): 117002, 2018

Long-term exposure to fine particulate matter air pollution and the risk of lung cancer among participants of the Canadian National Breast Screening Study. International Journal of Cancer 139(9): 1958-1966, 2017

Long-term Exposure to Fine Particulate Matter Air Pollution and Mortality Among Canadian Women. Epidemiology 26(4): 536-545, 2016

Long-term exposure to particulate matter in relation to mortality and incidence of cardiovascular disease: the JPHC Study. Journal of Atherosclerosis and Thrombosis 20(3): 296-309, 2013

Risk estimates of mortality attributed to low concentrations of ambient fine particulate matter in the Canadian community health survey cohort. Environmental Health 15: 18, 2016

Long-term exposure to high particulate matter pollution and cardiovascular mortality: a 12-year cohort study in four cities in northern China. Environment International 62: 41-47, 2014

Association between Long-Term Exposure to Particulate Matter Air Pollution and Mortality in a South Korean National Cohort: Comparison across Different Exposure Assessment Approaches. International Journal of Environmental Research and Public Health 14(10), 2018

Effect of long-term exposure to fine particulate matter on lung function decline and risk of chronic obstructive pulmonary disease in Taiwan: a longitudinal, cohort study. Lancet. Planetary Health 2(3): E114-E125, 2018

Chronic exposure to particulate matter and risk of cardiovascular mortality: cohort study from Taiwan. Bmc Public Health 15: 936, 2016

Exposure to particulate matter and long-term risk of cardiovascular mortality in Japan: NIPPON DATA80. Journal of Atherosclerosis and Thrombosis 19(3): 246-254, 2012

Risk of incident diabetes in relation to long-term exposure to fine particulate matter in Ontario, Canada. Environmental Health Perspectives 121(7): 804-810, 2014

Association of long-term exposure to fine particulate matter and incident dyslipidaemia: A longitudinal cohort study. Environmental Research 173: 359-365, 2019

Long-term exposure to ambient fine particulate matter and incidence of diabetes in China: A cohort study. Environment International 126: 568-575, 2019

Long-Term Exposure to Ambient Fine Particulate Matter and Chronic Kidney Disease: A Cohort Study. Environmental Health Perspectives 126(10): 107002, 2018