+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Risk of radiation-induced malignancy with heterotopic ossification prophylaxis: a case-control analysis



Risk of radiation-induced malignancy with heterotopic ossification prophylaxis: a case-control analysis



International Journal of Radiation Oncology, Biology, Physics 89(3): 584-589



To determine the risk of radiation-induced malignancy after prophylactic treatment for heterotopic ossification (HO). A matched case-control study was conducted within a population-based cohort of 3489 patients treated either for acetabular fractures with acetabular open reduction internal fixation or who underwent total hip arthroplasty from 1990 to 2009. Record-linkage techniques identified patients who were diagnosed with a malignancy from our state health registry. Patients with a prior history of malignancy were excluded from the cohort. For each documented case of cancer, 2 controls were selected by stratified random sampling from the cohort that did not develop a malignancy. Matching factors were sex, age at time of hip treatment, and duration of follow-up. A total of 243 patients were diagnosed with a malignancy after hip treatment. Five patients were excluded owing to inadequate follow-up time in the corresponding control cohort. A cohort of 238 cases (control, 476 patients) was included. Mean follow-up was 10 years, 12 years in the control group. In the cancer cohort, 4% of patients had radiation therapy (RT), compared with 7% in the control group. Of the 9 patients diagnosed with cancer after RT, none occurred within the field. The mean latency period was 5.9 years in the patients who received RT and 6.6 years in the patients who did not. Median (range) age at time of cancer diagnosis in patients who received RT was 62 (43-75) years, compared with 70 (32-92) years in the non-RT patients. An ad hoc analysis was subsequently performed in all 2749 patients who were not matched and found neither an increased incidence of malignancy nor a difference in distribution of type of malignancy. We were unable to demonstrate an increased risk of malignancy in patients who were treated with RT for HO prophylaxis compared with those who were not.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055586971

Download citation: RISBibTeXText

PMID: 24803038

DOI: 10.1016/j.ijrobp.2014.03.008


Related references

Not all second cancers are secondary. In regard to Mourad et al: "Radiation-induced sarcoma following radiation prophylaxis of heterotopic ossification". Practical Radiation Oncology 3(2): E35-E36, 2014

Radiation-induced sarcoma following radiation prophylaxis of heterotopic ossification. Practical Radiation Oncology 2(2): 151-154, 2012

Radiation therapy for heterotopic ossification prophylaxis afer high-risk elbow surgery. American Journal of Orthopedics 40(8): 400-405, 2012

Cancer risk estimates from radiation therapy for heterotopic ossification prophylaxis after total hip arthroplasty. Medical Physics 40(10): 101702-101702, 2014

Development and validation of a contextual behavioral distress intolerance task in cigarette smokers. Addictive Behaviors 87: 260-266, 2018

Radiation prophylaxis of heterotopic ossification. International Journal of Radiation Oncology, Biology, Physics 30(3): 743-744, 1994

Radiation therapy for heterotopic ossification prophylaxis. Ugeskrift for Laeger 176(24): -, 2014

Radiation prophylaxis for heterotopic ossification of the knee. Journal of Arthroplasty 16(1): 1-6, 2001

Peripheral organ doses from radiotherapy for heterotopic ossification of non-hip joints: is there a risk for radiation-induced malignancies?. Physica Medica 30(3): 309-313, 2015

Postsurgical radiation therapy for prophylaxis of heterotopic ossification. New Jersey Medicine 90(9): 672-674, 1993

Prophylaxis of heterotopic ossification in hip revisions with 7 Gy single-dose radiation. Zeitschrift für Orthopadie und Ihre Grenzgebiete 140(3): 317-322, 2002

Osteosarcoma following single fraction radiation prophylaxis for heterotopic ossification. Radiation Oncology 7: 140-140, 2013

Radiation prophylaxis for heterotopic ossification about the hip joint--a multicenter study. International Journal of Radiation Oncology, Biology, Physics 51(3): 756-765, 2001

Risk factors for posttraumatic heterotopic ossification of the elbow: case-control study. Journal of Hand Surgery 37(7): 1422-9.E1-6, 2012

Evaluation of scrotal and testicular radiation doses for heterotopic ossification prophylaxis. American Journal of Orthopedics 37(9): E163-E166, 2008