EurekaMag.com logo
+ Translate

Rituximab for non-Hodgkin's lymphoma: a story of rapid success in translation


, : Rituximab for non-Hodgkin's lymphoma: a story of rapid success in translation. Clinical and Translational Science 7(1): 82-86

Translational stories range from straightforward to complex. In this commentary, the story of the rapid and successful translation of rituximab therapy for the treatment of non-Hodgkin's lymphoma (NHL) is examined. Development of this monoclonal antibody therapy began in the late 1980s. In 1994, rituximab received its first approval for the treatment of NHL by the United States Food and Drug Administration (FDA). Rituximab has since been approved for additional indications and has transformed medical practice. However, the social and political implications of these rapid successes are only beginning to become clear. In this commentary, key events in the rapid translation of rituximab from the bench to bedside are highlighted and placed into this historical framework. To accomplish this, the story of rituximab is divided into the following six topics, which we believe to be widely applicable to case studies of translation: (1) underlying disease, (2) key basic science, (3) key clinical studies in translation, (4) FDA approval process, (5) changes to medical practice, and (6) the social and political influences on translation.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 055589976

PMID: 24528902

DOI: 10.1111/cts.12111

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Buzello, W.; Hoffmann, U.; Spillner, G., 1980: Pulmonary embolectomy using extracorporeal circulation. An anesthesiological and intensive care viewpoint. Three cases of massive pulmonary embolism are described in order to illustrate the indications for open pulmonary embolectomy with temporary cardiopulmonary bypass. Surgical treatment is mandatory in the presence of shock with systemic arterial hy...

Turner, Jd; Lockhart, R., 1987: Performance of a newly established Large White X Landrace gilt herd when housed during pregnancy in a single group in a strawed yard and electronically fed. BSAP occasional ication: an occasional ication of the British Society of Animal Production: 1) 143

Mazue G.; Remandet B.; Gouy D.; Berthe J.; Ronucci R.; Williams G.M., 1982: Limited in vivo bioassays on some benzodiazepines lack of experimental initiating or promoting effect of the benzodiazepine tranquilizers diazepam clorazepate oxazepam and lorazepam. Four benzodiazepine tranquilizers [diazepam, clorazepate, oxazepam and lorazepam] were tested for their ability to initiate or promote the development of preneoplastic and neoplastic rat liver lesions. In comparison with the liver carcinogen, N-2-...

Hardouin J.P., 1968: Hernia of the small intestine in a retro duodenal fossa. Semaine des Hopitaux de Paris 44(29): 1949-1950

White, B.C.; Winegar, C.D.; Wilson, R.F.; Hoehner, P.J.; Trombley, J.H., 1983: Possible role of calcium blockers in cerebral resuscitation: a review of the literature and synthesis for future studies. Critical Care Medicine 11(3): 202-207

Cowey, Cb, 1980: Protein and energy requirements. Nutrition and food science present knowledge and utilization(2): 171-176

Rao, A.S.; Liao, J.; Kabat, E.A.; Osserman, E.F.; Harboe, M.; Nimmich, W., 1984: Immunochemical studies on human monoclonal macroglobulins with specificities for 3,4-pyruvylated D-galactose and 4,6-pyruvylated D-glucose. Four of six human monoclonal IgM proteins were found to react best with Klebsiella polysaccharides containing 3,4py beta DGal (pyruvic acetalated D-galactopyranose), one with Klebsiella polysaccharides with 4,6pyDGlc; the sixth is uncharacterized....

Nikiforova, I. L., 1971: Mutation in the M2 of barley following treatment with chemical. Grains of Pallidum 65/196 were treated with solutions of N-nitroso-N-methylurea, N-nitroso-N-ethylurea (NEU), 1,4-bisdiazoacetylbutane and ethyleneimine and N-methyl-N-nitroso-p-tolylsulphonamide. All treatments induced mutations in the M2, but th...

Mallessard R., 1971: Experiences in guadeloupe on the feeding of pigs with banana m wastes. Fruits (Paris) 26(1): 20-22

Weinstein R.; Hoover G.A.; Majure J.; Van Der Spek J.; Stemerman M.B.; Maciag T., 1982: Growth of human fore skin fibroblasts in a serum free defined medium without platelet derived growth factor. The hormones which support growth, in vitro, of normal, neonatal human foreskin fibroblasts were determined. Thrombin and hydrocortisone were major growth stimulants, platelet-derived growth factor was not. Human foreskin fibroblasts grew in a ser...